Research output per year
Research output per year
Personal profile
Personal profile
After completing his postdoctoral training, Dr. Brown joined the faculty at the Baylor College of Medicine as a Clinical Instructor in the Department of Ophthalmology. He received his faculty appointment at the Weill Medical College in 2006.
Research interests
Dr. Brown’s research centers on clinical investigations to evaluate treatments for diabetic retinopathy, neovascular age-related macular degeneration, central retinal vein occlusion, and retinal detachment. Dr. Brown was a key investigator on the Anti-VEGF Antibody for the Treatment of Predominantly Classic Choroidal Neovascularization in Age-related Macular Degeneration (ANCHOR) Study and the Minimally classic/occult trial of the anti-VEGF antibody ranibizumab in the treatment of neovascular AMD (MARINA) Study which both demonstrated a statistically significant benefit of Lucentis (ranibizumab) over Visudyne (verteporfin photodynamic therapy [PDT]) in predominantly classic choroidal neovascularization (CNV). Dr. Brown is also a member of the Diabetic Retinopathy Clinical Research Network.
Education/Academic qualification
Vitreoretinal Diseases & Surgery, Clinical Fellowship
Jul 1 1993 → Jun 30 1995
Award Date: Jun 30 1995
MD, Baylor College of Medicine
May 1 1990 → Jun 1 1994
Award Date: Jun 1 1994
Ophthalmology, Residency, University of Iowa Hospitals and Clinics
Jul 1 1990 → Jun 30 1993
Award Date: Jun 30 1993
Internship, Baylor College of Medicine
Jul 1 1988 → Jun 30 1989
Award Date: Jun 30 1989
Research Area Keywords
- Clinical Care
- Clinical Translation & Trials
Free-text keywords
- Diabetic retinopathy
- Neovascular age-related macular degeneration
- Central retinal vein occlusion
- Retinal detachment
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Collaborations and top research areas from the last five years
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A Randomized Controlled Trial of OPT-302, a VEGF-C/D Inhibitor for Neovascular Age-Related Macular Degeneration
Opthea Study Group Investigators, Jun 2023, In: Ophthalmology. 130, 6, p. 588-597 10 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Baseline retinal vascular bed area on ultra-wide field fluorescein angiography correlates with the anatomical outcome of diabetic macular oedema to ranibizumab therapy: two-year analysis of the DAVE Study
Fan, W., Uji, A., Wykoff, C. C., Brown, D. M., van Hemert, J., Falavarjani, K. G., Wang, K., Sadda, S. V. R. & Ip, M., Mar 2023, In: Eye (Basingstoke). 37, 4, p. 678-683 6 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Demographic and Socioeconomic Factors in Prospective Retina-Focused Clinical Trial Screening and Enrollment
Cao, J. A., Patel, S. B., Wong, C. W., Garcia, D., Munoz, J., Cone, C., Zamora, D., Reagan, M., Nguyen, T. V., Pearce, W., Fish, R. H., Brown, D. M., Chaudhary, V., Wykoff, C. C. & Fan, K. C., May 23 2023, In: Journal of Personalized Medicine. 13, 6, 880.Research output: Contribution to journal › Article › peer-review
Open Access -
Effect of High-Dose Intravitreal Aflibercept, 8 mg, in Patients With Neovascular Age-Related Macular Degeneration: The Phase 2 CANDELA Randomized Clinical Trial
CANDELA Study Investigators, Sep 1 2023, In: JAMA Ophthalmology. 141, 9, p. 834-842 9 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Efficacy, durability, and safety of faricimab with extended dosing up to every 16 weeks in Japanese patients with diabetic macular edema: 1-year results from the Japan subgroup of the phase 3 YOSEMITE trial
on behalf of the YOSEMITE and RHINE Investigators, May 2023, In: Japanese Journal of Ophthalmology. 67, 3, p. 264-279 16 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations