Projects per year
Personal profile
Personal profile
Dr. Keith Chan received his PhD from the University of Texas Graduate School of Biomedical Sciences at MD Anderson Cancer Center in Houston, his BSc in Life Sciences from Queen’s University in Kingston, Ontario, Canada and was a postdoctoral fellow in cancer stem cells and immune evasion at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University in California. Dr. Chan most recently comes to Houston Methodist from Cedars-Sinai Medical Center where he was a professor of academic pathology and previously was a tenured associate professor of molecular and cellular biology at the Stem Cells and Regenerative Medicine (STaR) Center at the Baylor College of Medicine.
Research interests
With a focus on expediting the development of early-phase clinical trials and enhancing chemoimmunotherapy responses in bladder cancer, genitourinary cancer translational scientist Keith Syson Chan, PhD, is joining Houston Methodist thanks to a $6 million Established Investigator recruitment grant from the Cancer Prevention and Research Institute of Texas (CPRIT).
Research Area Keywords
- Cancer
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Collaborations and top research areas from the last five years
Projects
- 10 Active
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The stromal microenvironment as a co-organizer of bladder carcinogenesis and progression
9/1/23 → 8/31/27
Project: Federal Funding Agencies
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Spatial and mechanistic assessment of the role of stromal fibroblasts in driving emergence of aggressive prostate and bladder cancer
9/1/23 → 8/31/27
Project: Federal Funding Agencies
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The stromal microenvironment as a co-organizer of bladder carcinogenesis and progression
9/1/23 → 8/31/27
Project: Federal Funding Agencies
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The stromal microenvironment as a co-organizer of bladder carcinogenesis and progression
9/1/23 → 8/31/27
Project: Federal Funding Agencies
-
The stromal microenvironment as a co-organizer of bladder carcinogenesis and progression
9/1/23 → 8/31/27
Project: Federal Funding Agencies
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Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors
Nikolos, F., Hayashi, K., Hoi, X. P., Alonzo, M. E., Mo, Q., Kasabyan, A., Furuya, H., Trepel, J., Di Vizio, D., Guarnerio, J., Theodorescu, D., Rosser, C., Apolo, A., Galsky, M. & Chan, K. S., Dec 2022, In: Nature Communications. 13, 1, 1487.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
The dynamic roles of the bladder tumour microenvironment
Lee, Y. C., Lam, H. M., Rosser, C., Theodorescu, D., Parks, W. C. & Chan, K. S., Sep 2022, In: Nature Reviews Urology. 19, 9, p. 515-533 19 p.Research output: Contribution to journal › Review article › peer-review
17 Scopus citations -
Comparative real-world survival outcomes of muscle-invasive bladder cancer treated with bladder-only vs. whole-pelvis concurrent chemoradiation
Riveros, C., Ranganathan, S., Haque, W., Huang, E., Xu, J., Kulkarni, G. S., Geng, M., Anis, M., Muhammad, T., Chan, K. S., Farach, A., Teh, B. S., Miles, B. J., Klaassen, Z., Sonpavde, G. P., Wallis, C. J. D. & Satkunasivam, R., Feb 2024, In: Journal of the Canadian Urological Association. 18, 2, p. 17-24 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors
Heiser, C. N., Simmons, A. J., Revetta, F., McKinley, E. T., Ramirez-Solano, M. A., Wang, J., Kaur, H., Shao, J., Ayers, G. D., Wang, Y., Glass, S. E., Tasneem, N., Chen, Z., Qin, Y., Kim, W., Rolong, A., Chen, B., Vega, P. N., Drewes, J. L., Markham, N. O., & 13 others , Dec 7 2023, In: Cell. 186, 25, p. 5620-5637.e16Research output: Contribution to journal › Article › peer-review
Open Access -
Cabozantinib plus Nivolumab Phase I Expansion Study in Patients with Metastatic Urothelial Carcinoma Refractory to Immune Checkpoint Inhibitor Therapy
Girardi, D. M., Niglio, S. A., Mortazavi, A., Nadal, R., Lara, P., Pal, S. K., Saraiya, B., Cordes, L., Ley, L., Ortiz, O. S., Cadena, J., Diaz, C., Bagheri, H., Redd, B., Steinberg, S. M., Costello, R., Chan, K. S., Lee, M. J., Lee, S., Yu, Y., & 15 others , Apr 1 2022, In: Clinical Cancer Research. 28, 7, p. 1353-1362 10 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations