Projects per year
Personal profile
Personal profile
Dr. Keith Chan received his PhD from the University of Texas Graduate School of Biomedical Sciences at MD Anderson Cancer Center in Houston, his BSc in Life Sciences from Queen’s University in Kingston, Ontario, Canada and was a postdoctoral fellow in cancer stem cells and immune evasion at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University in California. Dr. Chan most recently comes to Houston Methodist from Cedars-Sinai Medical Center where he was a professor of academic pathology and previously was a tenured associate professor of molecular and cellular biology at the Stem Cells and Regenerative Medicine (STaR) Center at the Baylor College of Medicine.
Research interests
With a focus on expediting the development of early-phase clinical trials and enhancing chemoimmunotherapy responses in bladder cancer, genitourinary cancer translational scientist Keith Syson Chan, PhD, is joining Houston Methodist thanks to a $6 million Established Investigator recruitment grant from the Cancer Prevention and Research Institute of Texas (CPRIT).
Research Area Keywords
- Cancer
Free-text keywords
- Fibroblast and collagen signaling
- immunogenic cell death
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Collaborations and top research areas from the last five years
Projects
- 12 Active
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Molecular Analysis of tumors and liquid biopsies in Patients undergoing standard treatment for Bladder Cancer and correlation to clinical outcomes (MAP Bladder)
Satkunasivam, R. (PI), Chan, K. S. (Key Personnel) & Miles, B. J. (Key Personnel)
4/9/24 → …
Project: Clinical Trial
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The stromal microenvironment as a co-organizer of bladder carcinogenesis and progression
Chan, K. S. (PI)
9/1/23 → 8/31/27
Project: Federal Funding Agencies
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The stromal microenvironment as a co-organizer of bladder carcinogenesis and progression
Chan, K. S. (PI)
9/1/23 → 8/31/27
Project: Federal Funding Agencies
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Spatial and mechanistic assessment of the role of stromal fibroblasts in driving emergence of aggressive prostate and bladder cancer
Chan, K. S. (PI)
9/1/23 → 8/31/27
Project: Federal Funding Agencies
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The stromal microenvironment as a co-organizer of bladder carcinogenesis and progression
Chan, K. S. (PI)
9/1/23 → 8/31/27
Project: Federal Funding Agencies
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The dynamic roles of the bladder tumour microenvironment
Lee, Y. C., Lam, H. M., Rosser, C., Theodorescu, D., Parks, W. C. & Chan, K. S., Sep 2022, In: Nature Reviews Urology. 19, 9, p. 515-533 19 p.Research output: Contribution to journal › Review article › peer-review
28 Scopus citations -
Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors
Nikolos, F., Hayashi, K., Hoi, X. P., Alonzo, M. E., Mo, Q., Kasabyan, A., Furuya, H., Trepel, J., Di Vizio, D., Guarnerio, J., Theodorescu, D., Rosser, C., Apolo, A., Galsky, M. & Chan, K. S., Dec 2022, In: Nature Communications. 13, 1, 1487.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Discoidin Domain Receptor-Driven Gene Signatures as Markers of Patient Response to Anti-PD-L1 Immune Checkpoint Therapy
You, S., Kim, M., Hoi, X. P., Lee, Y. C., Wang, L., Spetzler, D., Abraham, J., Magee, D., Jain, P., Galsky, M. D., Chan, K. S. & Theodorescu, D., Oct 1 2022, In: Journal of the National Cancer Institute. 114, 10, p. 1380-1391 12 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
Hayashi, K., Nikolos, F., Lee, Y. C., Jain, A., Tsouko, E., Gao, H., Kasabyan, A., Leung, H. E., Osipov, A., Jung, S. Y., Kurtova, A. V. & Chan, K. S., Dec 2020, In: Nature Communications. 11, 1, 6299.Research output: Contribution to journal › Article › peer-review
Open Access152 Scopus citations -
Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung
Lee, Y. C., Kurtova, A. V., Xiao, J., Nikolos, F., Hayashi, K., Tramel, Z., Jain, A., Chen, F., Chokshi, M., Lee, C., Bao, G., Zhang, X., Shen, J., Mo, Q., Jung, S. Y., Rowley, D. & Chan, K. S., Dec 1 2019, In: Nature Communications. 10, 1, 2131.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations