@article{208f6b0e82d34376bceeb3a6e81332f8,
title = "帕金森病患者尸检迷走神经病理和肠道神经炎症分析",
abstract = "Objective： To investigate the roles of neuroinflammation and pathology of peripheral nervous system in the pathogenesis of Parkinson{\textquoteright}s disease (PD). Methods： Immunohistochemical staining was performed to examine the nodose ganglia (containing vagus nerve) and intestine of an autopsy case of PD. The neuroinflammation and morphological changes of vagus nerve and enteric nervous system were observed. Results： The expressions and distributions of glial fibrillary acidic protein and ionized calcium binding adapter molecule 1, two typical glia cell biomarkers, were different in vagus nerve and intestinal mucosa. Tumor necrosis factor α and inducible nitric oxide synthase were expressed in intestinal mucosa and myenteric plexus of the PD patient. There was a strong inflammatory reaction in the myenteric plexus, which distributed diffusely. Conclusion： Satellite glial cells and intestinal inflammatory response may play a role in the pathogenesis of PD.",
keywords = "Enteric glial cells, Neuroinflammation, Parkinson disease, Vagus nerve",
author = "Zhaofei Yang and Lei Sun and Daqing Kou and Tianbai Li and Zhigang Sun and Weidong Le",
note = "Funding Information: Yang Zhaofei1, Sun Lei2, Kou Daqing3, Li Tianbai1, Sun Zhigang4, Le Weidong1 1Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116021, China;2Department of Pathology, Dalian Medical University, Dalian, Liaoning 116044, China;3Department of Clinical Laboratory, the First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116021, China;4 Department of Pathology, the First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116021, China Corresponding author: Le Weidong, Email: wdle@sibs.ac.cn 【Abstract】 Objective To investigate the roles of neuroinflammation and pathology of peripheral nervous system in the pathogenesis of Parkinson′s disease (PD). Methods Immunohistochemical staining was performed to examine the nodose ganglia (containing vagus nerve) and intestine of an autopsy case of PD. The neuroinflammation and morphological changes of vagus nerve and enteric nervous system were observed. Results The expressions and distributions of glial fibrillary acidic protein and ionized calcium binding adapter molecule 1, two typical glia cell biomarkers, were different in vagus nerve and intestinal mucosa. Tumor necrosis factor α and inducible nitric oxide synthase were expressed in intestinal mucosa and myenteric plexus of the PD patient. There was a strong inflammatory reaction in the myenteric plexus, which distributed diffusely. Conclusion Satellite glial cells and intestinal inflammatory response may play a role in the pathogenesis of PD. 【Key words】 Parkinson disease; Neuroinflammation; Enteric glial cells; Vagus nerve Fund program: Key Project of the National Natural Science Foundation of China (81430021); General Program of the National Natural Science Foundation of China (81771521) Conflicts of interest: None declared DOI: 10.3760/cma.j.issn.1006⁃7876.2019.05.005 Publisher Copyright: {\textcopyright}2019， by the Chinese Medical Association. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
month = may,
day = "8",
doi = "10.3760/cma.j.issn.1006-7876.2019.05.005",
language = "Chinese (Traditional)",
volume = "52",
pages = "387--393",
journal = "Chinese Journal of Neurology",
issn = "1006-7876",
publisher = "Chinese Medical Association",
number = "5",
}