2.32 - Microbiota-Brain-Gut Axis and Neurodegenerative Disorders

Shaadi J. Abughazaleh; Lindsay A. Euers; Eamonn M.M. Quigley

doi:10.1016/B978-0-12-819265-8.00031-0

2.32 - Microbiota-Brain-Gut Axis and Neurodegenerative Disorders

Shaadi J. Abughazaleh, Lindsay A. Euers, Eamonn M.M. Quigley

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

A bi-directional channel of communication, the gut-brain axis, has been recognized for decades; now another dimension is added, the gut microbiome. Evidence now indicates a critical role for gut microbes in brain development and function; findings that have spurred a plethora of studies into relationships between gut microbiota profiles and neurodegenerative disorders. While findings in animal models suggest that a disturbed gut microbiome might contribute to the pathophysiology of neurological disorders, a causative relationship has yet to be defined and effective therapeutic strategies based on microbiota modulation have not, as yet, emerged.

Original language	English (US)
Title of host publication	Comprehensive Gut Microbiota
Publisher	Elsevier
Pages	412-422
Number of pages	11
Volume	2
ISBN (Electronic)	9780128192658
ISBN (Print)	9780128220368
DOIs	https://doi.org/10.1016/B978-0-12-819265-8.00031-0
State	Published - Jan 1 2022

Keywords

Alzheimer's disease
Amyotrophic lateral sclerosis
Antibiotic
Central nervous system
Diet
Fecal microbiota transplantation
Gut-brain axis
Huntington's disease
Microbiome
Microbiota
Multiple sclerosis
Neurodegeneration
Parkinson's disease
Prebiotic
Probiotic

ASJC Scopus subject areas

Immunology and Microbiology(all)

Access to Document

10.1016/B978-0-12-819265-8.00031-0

Cite this

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title = "2.32 - Microbiota-Brain-Gut Axis and Neurodegenerative Disorders",

abstract = "A bi-directional channel of communication, the gut-brain axis, has been recognized for decades; now another dimension is added, the gut microbiome. Evidence now indicates a critical role for gut microbes in brain development and function; findings that have spurred a plethora of studies into relationships between gut microbiota profiles and neurodegenerative disorders. While findings in animal models suggest that a disturbed gut microbiome might contribute to the pathophysiology of neurological disorders, a causative relationship has yet to be defined and effective therapeutic strategies based on microbiota modulation have not, as yet, emerged.",

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AU - Euers, Lindsay A.

AU - Quigley, Eamonn M.M.

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KW - Amyotrophic lateral sclerosis

KW - Antibiotic

KW - Central nervous system

KW - Diet

KW - Fecal microbiota transplantation

KW - Gut-brain axis

KW - Huntington's disease

KW - Microbiome

KW - Microbiota

KW - Multiple sclerosis

KW - Neurodegeneration

KW - Parkinson's disease

KW - Prebiotic

KW - Probiotic

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BT - Comprehensive Gut Microbiota

PB - Elsevier

ER -

2.32 - Microbiota-Brain-Gut Axis and Neurodegenerative Disorders

Abstract

Keywords

ASJC Scopus subject areas

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