TY - JOUR
T1 - 2,3,7,8-tetrachlorodibenzo-p-dioxin as an antiestrogen
T2 - Effect on rat uterine peroxidase activity
AU - Astroff, Barry
AU - Safe, Stephen
N1 - Funding Information:
Acknowledgements-The financial assistance of the Texas Agricultural Experiment Station and the AUF is gratefully acknowledged. S. Safe is a Burroughs Wellcome Toxicology Scholar.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1990/2/1
Y1 - 1990/2/1
N2 - Treatment of 25-day-old female Sprague-Dawley rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) significantly lowered constitutive uterine peroxidase activity and decreased uterine wet weights in a dose-response fashion. In cotreatment studies with 17β-estradiol, 2,3,7,8-TCDD antagonized the increase in uterine peroxidase activity and uterine wet weights, and these effects persisted for up to 156 hr. In the rat uterus, the antiestrogenic affects of two potent Ah receptor agonists, 2,3,7.8-TCDD and 2,3,4,7,8-pentachlorodibenzofuran, were comparable at a dose of 80μ/kg, whereas the weaker Ah receptor agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin, was relatively inactive at this dose. These results show that 2,3,7,8-TCDD antagonizes a well-characterized estrogen-induced response (uterine peroxidase activity), and the structure-activity data suggest that the Ah receptor is involved in mediating the antiestrogenic responses in target cells/organs.
AB - Treatment of 25-day-old female Sprague-Dawley rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) significantly lowered constitutive uterine peroxidase activity and decreased uterine wet weights in a dose-response fashion. In cotreatment studies with 17β-estradiol, 2,3,7,8-TCDD antagonized the increase in uterine peroxidase activity and uterine wet weights, and these effects persisted for up to 156 hr. In the rat uterus, the antiestrogenic affects of two potent Ah receptor agonists, 2,3,7.8-TCDD and 2,3,4,7,8-pentachlorodibenzofuran, were comparable at a dose of 80μ/kg, whereas the weaker Ah receptor agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin, was relatively inactive at this dose. These results show that 2,3,7,8-TCDD antagonizes a well-characterized estrogen-induced response (uterine peroxidase activity), and the structure-activity data suggest that the Ah receptor is involved in mediating the antiestrogenic responses in target cells/organs.
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U2 - 10.1016/0006-2952(90)90054-O
DO - 10.1016/0006-2952(90)90054-O
M3 - Article
C2 - 2154986
AN - SCOPUS:0025097868
SN - 0006-2952
VL - 39
SP - 485
EP - 488
JO - Biochemical pharmacology
JF - Biochemical pharmacology
IS - 3
ER -