TY - JOUR
T1 - 4-Hydroxy-2-nonenal, a lipid peroxidation product, as a biomarker in diabetes and its complications
T2 - challenges and opportunities
AU - Dham, Deiva
AU - Roy, Bipradas
AU - Gowda, Amita
AU - Pan, Guodong
AU - Sridhar, Arun
AU - Zeng, Xiangqun
AU - Thandavarayan, Rajarajan A.
AU - Palaniyandi, Suresh Selvaraj
N1 - Funding Information:
SSP is supported by a grant from the National Heart, Lung, and Blood Institute [grant no. 1R01HL139877-01A1] and an internal grant from Henry Ford Health System [grant no. A10249].
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021/5
Y1 - 2021/5
N2 - Over 30 million Americans are diagnosed with diabetes and this number is only expected to increase. There are various causes that induce complications with diabetes, including oxidative stress. In oxidative stress, lipid peroxidation-derived reactive carbonyl species such as 4-hydroxy-2-nonenal (4-HNE) is shown to cause damage in organs that leads to diabetic complications. We provided evidence to show that 4-HNE or/and 4-HNE-protein adducts are elevated in various organ systems of diabetic patients and animal models. We then discussed the advantages and disadvantages of different methodologies used for the detection of 4-HNE in diabetic tissues. We also discussed how novel approaches such as electrochemistry and nanotechnology can be used for monitoring 4-HNE levels in biological systems in real-time. Thus, this review enlightens the involvement of 4-HNE in the pathogenesis of diabetes and its complications and efficient methods to identify it. Furthermore, the article presents that 4-HNE can be developed as a biomarker for end-organ damage in diabetes such as diabetic cardiac complications.
AB - Over 30 million Americans are diagnosed with diabetes and this number is only expected to increase. There are various causes that induce complications with diabetes, including oxidative stress. In oxidative stress, lipid peroxidation-derived reactive carbonyl species such as 4-hydroxy-2-nonenal (4-HNE) is shown to cause damage in organs that leads to diabetic complications. We provided evidence to show that 4-HNE or/and 4-HNE-protein adducts are elevated in various organ systems of diabetic patients and animal models. We then discussed the advantages and disadvantages of different methodologies used for the detection of 4-HNE in diabetic tissues. We also discussed how novel approaches such as electrochemistry and nanotechnology can be used for monitoring 4-HNE levels in biological systems in real-time. Thus, this review enlightens the involvement of 4-HNE in the pathogenesis of diabetes and its complications and efficient methods to identify it. Furthermore, the article presents that 4-HNE can be developed as a biomarker for end-organ damage in diabetes such as diabetic cardiac complications.
KW - 4-hydroxy-2-nonenal (4-HNE)
KW - Diabetes
KW - diabetic cardiac complications
KW - electrochemistry
KW - reactive carbonyl species
KW - Animals
KW - Reactive Oxygen Species
KW - Oxidative Stress
KW - Humans
KW - Lipid Peroxidation/immunology
KW - Biomarkers/metabolism
KW - Diabetes Mellitus/blood
UR - http://www.scopus.com/inward/record.url?scp=85099056010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85099056010&partnerID=8YFLogxK
U2 - 10.1080/10715762.2020.1866756
DO - 10.1080/10715762.2020.1866756
M3 - Review article
C2 - 33336611
AN - SCOPUS:85099056010
SN - 1071-5762
VL - 55
SP - 547
EP - 561
JO - Free Radical Research
JF - Free Radical Research
IS - 5
ER -