Abstract
In this study, a berberine-loaded electrospun poly-(ε-caprolactone) nanofibrous membrane (B-NFM) was formulated. The B-NFM was composed of uniform nanofibers with the average diameter of 190±53 nm. Whole blood assay revealed that the B-NFM had higher absorption capacity than gauze wound dressing (GWD) and non-drug-loaded nanofibrous membrane (NFM). Hemostatic studies showed that the B-NFM was more efficient at promoting blood clotting than GWD and NFM. B-NFM was also demonstrated to possess broad-spectrum antimicrobial activity. Biocompatibility studies indicated that B-NFM had good compatibility with skin fibroblast cells. These results suggested that the B-NFM can promote in vitro hemostasis to minimize wound bleeding, absorb biofluid to provide a favorable environment, inhibit on-site microbial agents to prevent wound infection, and support skin cell growth to facilitate wound healing. These data highly suggest a potential clinical use of B-NFM as wound dressing material.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1173-1180 |
| Number of pages | 8 |
| Journal | Journal of Biomedical Nanotechnology |
| Volume | 9 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2013 |
Keywords
- Antimicrobial
- Berberine
- Hemostatic
- Membrane
- Nanofibers
- Wound dressing
ASJC Scopus subject areas
- Materials Science(all)
- Bioengineering
- Biomedical Engineering
- Medicine (miscellaneous)
- Pharmaceutical Science