A biologic without guidelines: The YODA project and the future of bone morphogenetic protein-2 research

Eugene J. Carragee; Ray M. Baker; Edward C. Benzel; Stanley J. Bigos; Ivan Cheng; Terry P. Corbin; Richard A. Deyo; Eric L. Hurwitz; Jeffrey G. Jarvik; James D. Kang; Jon D. Lurie; Thomas E. Mroz; F. Cumhur Öner; Wilco C. Peul; James Rainville; John K. Ratliff; Jeffrey A. Rihn; David J. Rothman; Mark L. Schoene; Dan M. Spengler; Bradley K. Weiner

doi:10.1016/j.spinee.2012.11.002

A biologic without guidelines: The YODA project and the future of bone morphogenetic protein-2 research

Eugene J. Carragee, Ray M. Baker, Edward C. Benzel, Stanley J. Bigos, Ivan Cheng, Terry P. Corbin, Richard A. Deyo, Eric L. Hurwitz, Jeffrey G. Jarvik, James D. Kang, Jon D. Lurie, Thomas E. Mroz, F. Cumhur Öner, Wilco C. Peul, James Rainville, John K. Ratliff, Jeffrey A. Rihn, David J. Rothman, Mark L. Schoene, Dan M. SpenglerBradley K. Weiner

Research output: Contribution to journal › Editorial › peer-review

33 Scopus citations

Original language	English (US)
Pages (from-to)	877-880
Number of pages	4
Journal	Spine Journal
Volume	12
Issue number	10
DOIs	https://doi.org/10.1016/j.spinee.2012.11.002
State	Published - Oct 2012

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine
Clinical Neurology

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10.1016/j.spinee.2012.11.002

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Carragee, E. J., Baker, R. M., Benzel, E. C., Bigos, S. J., Cheng, I., Corbin, T. P., Deyo, R. A., Hurwitz, E. L., Jarvik, J. G., Kang, J. D., Lurie, J. D., Mroz, T. E., Öner, F. C., Peul, W. C., Rainville, J., Ratliff, J. K., Rihn, J. A., Rothman, D. J., Schoene, M. L., ... Weiner, B. K. (2012). A biologic without guidelines: The YODA project and the future of bone morphogenetic protein-2 research. Spine Journal, 12(10), 877-880. https://doi.org/10.1016/j.spinee.2012.11.002

Carragee, EJ, Baker, RM, Benzel, EC, Bigos, SJ, Cheng, I, Corbin, TP, Deyo, RA, Hurwitz, EL, Jarvik, JG, Kang, JD, Lurie, JD, Mroz, TE, Öner, FC, Peul, WC, Rainville, J, Ratliff, JK, Rihn, JA, Rothman, DJ, Schoene, ML, Spengler, DM & Weiner, BK 2012, 'A biologic without guidelines: The YODA project and the future of bone morphogenetic protein-2 research', Spine Journal, vol. 12, no. 10, pp. 877-880. https://doi.org/10.1016/j.spinee.2012.11.002

@article{4974c11d664a4671ab124d5c050f5e26,

title = "A biologic without guidelines: The YODA project and the future of bone morphogenetic protein-2 research",

author = "Carragee, {Eugene J.} and Baker, {Ray M.} and Benzel, {Edward C.} and Bigos, {Stanley J.} and Ivan Cheng and Corbin, {Terry P.} and Deyo, {Richard A.} and Hurwitz, {Eric L.} and Jarvik, {Jeffrey G.} and Kang, {James D.} and Lurie, {Jon D.} and Mroz, {Thomas E.} and {\"O}ner, {F. Cumhur} and Peul, {Wilco C.} and James Rainville and Ratliff, {John K.} and Rihn, {Jeffrey A.} and Rothman, {David J.} and Schoene, {Mark L.} and Spengler, {Dan M.} and Weiner, {Bradley K.}",

note = "Funding Information: Author disclosures: EJC: Stock Ownership: Intrinsic Spine (B), Bioassetts (B); Private Investments: Simpirica (D); Research Support (Investigator Salary): NIH (C, Paid directly to institution); Trips/Travel: The Spine Journal (A); Other Office: NASS/The Spine Journal (E, Editor in Chief); Fellowship Support: OREF (E, Paid directly to institution), AO Foundation (E, Paid directly to institution). RMB: Stock Ownership: Relievant MedSystems (100,000 Shares, <1% ownership); Private Investments: Nocimed (190,706 Shares, 2.45% ownership), Laurimed (30,000 Shares, <1% ownership); Board of Directors: NASS (President), ISIS (President). ECB: Nothing to disclose. SJB: Royalties: BackBook (A); Speaking/Teaching Arrangements: Mayo Clinic (B). IC: Royalties: Nuvasive (C); Stock Ownership: Nuvasive (B); Consulting: Stryker Spine (C); Grants: OREF (F, paid directly to institution). TPC: Royalties: Quality Medical Publishing (A); Stock Ownership: Kinetic Concepts, Inc. (300 Shares, <1%); Private Investments: Spinal Therapies, LLC (10,000 Shares, 3%), Amedica Corporation (1,218 Shares, 1%, stock options); Consulting: Kinetic Concepts, Inc. (D), Amedica Corporation (D), Synthes Spine (B), Replication Medical (C), Anulex (B), Vertebral Technologies, Inc. (B); Trips/Travel: Kinetic Concept (B), Synthes Spine (B); Research Support (Investigator Salary): Zimmer Spine (A). RAD: Consulting: UpToDate (A, paid directly to institution); Board of Directors: Foundation for Informed Medical Decision-Making (B); Scientific Advisory Board/Other Office: National Advisory Committee for the Robert Wood Johnson Foundation Physicial Faculty Scholars Program (B); Endowments: Kaiser Permanente Professorship for Evidence-Based Family Medicine (H, paid directly to institution); Grants: NIH (I, paid directly to institution). ELH: Consulting: Society for Chiropractic Orthospinology, Inc. (B), Western University of Health Sciences (B), National Institutes of Health (B), Southern California University of Health Sciences (B), George Mason University (B), The North Carolina State Health Plan for Teachers and State Employees (B); Trips/Travel: World Spine Care (B), The Spine Journal (A); Other Office: The Spine Journal (C, Deputy Editor); Other: Palmer Center for Chiropractic Research (B). JGJ: Stock Ownership: PhysioSonics (unknown amount); Consulting: HealthHelp (C); Trips/Travel: GE-AUR Radiology Research Academic Fellowship (A); Scientific Advisory Board/Other Office: GE Healthcare-CER (B). JDK: Research Support: Stryker (E). JDL: Consulting: Foundation for Informed Medical Decision Making (B), Baxano (B), Blue Cross Blue Shield (B); Scientific Advisory Board: Sanofi-Aventis (B). TEM: Stock Ownership: Pearl Diver, Inc. (none); Consulting: Globus (B); Speaking/Teaching Arrangements: AOSpine North America (B); Fellowship Support: AOSpine (E). FCO: Nothing to disclose. WCP: Speaking and/or Teaching Arrangements: Several scientific societies (B, paid directly to institution); Grants: ZonMW (F), CVZ (F), Medtronic (F), Paradigm Spine (F); Fellowship Support: EANS (C), ISSLS (C). JR: Royalties: Biomet Spine (E); Stock Ownership: Johnson and Johnson (sold shares, amount not disclosed); Consulting: Stryker Spine (D). JKR: Nothing to disclose. JAR: Other Office: Federation of Spine Associations (President); Grants: DePuy Spine (D, paid directly to institution). DJR: Other relationships: State of Texas (E). MLS: Consulting: Informed Medical Decisions Foundation (B); Board of Directors: Cochrane Collaboration Back Review Group (Editorial Board); Other Relationships: Lippincott Williams & Wilkins (F, Editor of The Back Letter). DMS: Nothing to disclose. BKW: Trips/Travel: The Spine Journal (A); Other Office: The Spine Journal (None, Deputy Editor); Other: Intrinsic Therapeutics (B). ",

year = "2012",

month = oct,

doi = "10.1016/j.spinee.2012.11.002",

language = "English (US)",

volume = "12",

pages = "877--880",

journal = "Spine Journal",

issn = "1529-9430",

publisher = "Elsevier",

number = "10",

}

TY - JOUR

T1 - A biologic without guidelines

T2 - The YODA project and the future of bone morphogenetic protein-2 research

AU - Carragee, Eugene J.

AU - Baker, Ray M.

AU - Benzel, Edward C.

AU - Bigos, Stanley J.

AU - Cheng, Ivan

AU - Corbin, Terry P.

AU - Deyo, Richard A.

AU - Hurwitz, Eric L.

AU - Jarvik, Jeffrey G.

AU - Kang, James D.

AU - Lurie, Jon D.

AU - Mroz, Thomas E.

AU - Öner, F. Cumhur

AU - Peul, Wilco C.

AU - Rainville, James

AU - Ratliff, John K.

AU - Rihn, Jeffrey A.

AU - Rothman, David J.

AU - Schoene, Mark L.

AU - Spengler, Dan M.

AU - Weiner, Bradley K.

N1 - Funding Information: Author disclosures: EJC: Stock Ownership: Intrinsic Spine (B), Bioassetts (B); Private Investments: Simpirica (D); Research Support (Investigator Salary): NIH (C, Paid directly to institution); Trips/Travel: The Spine Journal (A); Other Office: NASS/The Spine Journal (E, Editor in Chief); Fellowship Support: OREF (E, Paid directly to institution), AO Foundation (E, Paid directly to institution). RMB: Stock Ownership: Relievant MedSystems (100,000 Shares, <1% ownership); Private Investments: Nocimed (190,706 Shares, 2.45% ownership), Laurimed (30,000 Shares, <1% ownership); Board of Directors: NASS (President), ISIS (President). ECB: Nothing to disclose. SJB: Royalties: BackBook (A); Speaking/Teaching Arrangements: Mayo Clinic (B). IC: Royalties: Nuvasive (C); Stock Ownership: Nuvasive (B); Consulting: Stryker Spine (C); Grants: OREF (F, paid directly to institution). TPC: Royalties: Quality Medical Publishing (A); Stock Ownership: Kinetic Concepts, Inc. (300 Shares, <1%); Private Investments: Spinal Therapies, LLC (10,000 Shares, 3%), Amedica Corporation (1,218 Shares, 1%, stock options); Consulting: Kinetic Concepts, Inc. (D), Amedica Corporation (D), Synthes Spine (B), Replication Medical (C), Anulex (B), Vertebral Technologies, Inc. (B); Trips/Travel: Kinetic Concept (B), Synthes Spine (B); Research Support (Investigator Salary): Zimmer Spine (A). RAD: Consulting: UpToDate (A, paid directly to institution); Board of Directors: Foundation for Informed Medical Decision-Making (B); Scientific Advisory Board/Other Office: National Advisory Committee for the Robert Wood Johnson Foundation Physicial Faculty Scholars Program (B); Endowments: Kaiser Permanente Professorship for Evidence-Based Family Medicine (H, paid directly to institution); Grants: NIH (I, paid directly to institution). ELH: Consulting: Society for Chiropractic Orthospinology, Inc. (B), Western University of Health Sciences (B), National Institutes of Health (B), Southern California University of Health Sciences (B), George Mason University (B), The North Carolina State Health Plan for Teachers and State Employees (B); Trips/Travel: World Spine Care (B), The Spine Journal (A); Other Office: The Spine Journal (C, Deputy Editor); Other: Palmer Center for Chiropractic Research (B). JGJ: Stock Ownership: PhysioSonics (unknown amount); Consulting: HealthHelp (C); Trips/Travel: GE-AUR Radiology Research Academic Fellowship (A); Scientific Advisory Board/Other Office: GE Healthcare-CER (B). JDK: Research Support: Stryker (E). JDL: Consulting: Foundation for Informed Medical Decision Making (B), Baxano (B), Blue Cross Blue Shield (B); Scientific Advisory Board: Sanofi-Aventis (B). TEM: Stock Ownership: Pearl Diver, Inc. (none); Consulting: Globus (B); Speaking/Teaching Arrangements: AOSpine North America (B); Fellowship Support: AOSpine (E). FCO: Nothing to disclose. WCP: Speaking and/or Teaching Arrangements: Several scientific societies (B, paid directly to institution); Grants: ZonMW (F), CVZ (F), Medtronic (F), Paradigm Spine (F); Fellowship Support: EANS (C), ISSLS (C). JR: Royalties: Biomet Spine (E); Stock Ownership: Johnson and Johnson (sold shares, amount not disclosed); Consulting: Stryker Spine (D). JKR: Nothing to disclose. JAR: Other Office: Federation of Spine Associations (President); Grants: DePuy Spine (D, paid directly to institution). DJR: Other relationships: State of Texas (E). MLS: Consulting: Informed Medical Decisions Foundation (B); Board of Directors: Cochrane Collaboration Back Review Group (Editorial Board); Other Relationships: Lippincott Williams & Wilkins (F, Editor of The Back Letter). DMS: Nothing to disclose. BKW: Trips/Travel: The Spine Journal (A); Other Office: The Spine Journal (None, Deputy Editor); Other: Intrinsic Therapeutics (B).

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Y1 - 2012/10

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A biologic without guidelines: The YODA project and the future of bone morphogenetic protein-2 research

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