A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors

Mi-Ran Choi; Katie J Stanton-Maxey; Jennifer K Stanley; Carly S Levin; Rizia Bardhan; Demir Akin; Sunil Badve; Jennifer E. Sturgis; J Paul Robinson; Rashid Bashir; Naomi J. Halas; Susan E Clare

doi:10.1021/nl072209h

A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors

Mi-Ran Choi, Katie J Stanton-Maxey, Jennifer K Stanley, Carly S Levin, Rizia Bardhan, Demir Akin, Sunil Badve, Jennifer E. Sturgis, J Paul Robinson, Rashid Bashir, Naomi J. Halas, Susan E Clare

Research output: Contribution to journal › Article › peer-review

521 Scopus citations

Abstract

Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

Original language	English (US)
Pages (from-to)	3759-65
Number of pages	7
Journal	Nano Letters
Volume	7
Issue number	12
DOIs	https://doi.org/10.1021/nl072209h
State	Published - Dec 2007

Keywords

Antineoplastic Agents
Biological Transport
Cell Hypoxia
Drug Delivery Systems
Humans
Macrophages
Monocytes
Nanoparticles
Neoplasms
Spectrophotometry
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

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10.1021/nl072209h

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@article{93199e7eb2004cfd8a38a324ffe96934,

title = "A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors",

abstract = "Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as {"}Trojan Horses{"} for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.",

keywords = "Antineoplastic Agents, Biological Transport, Cell Hypoxia, Drug Delivery Systems, Humans, Macrophages, Monocytes, Nanoparticles, Neoplasms, Spectrophotometry, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.",

author = "Mi-Ran Choi and Stanton-Maxey, {Katie J} and Stanley, {Jennifer K} and Levin, {Carly S} and Rizia Bardhan and Demir Akin and Sunil Badve and Sturgis, {Jennifer E.} and Robinson, {J Paul} and Rashid Bashir and Halas, {Naomi J.} and Clare, {Susan E}",

year = "2007",

month = dec,

doi = "10.1021/nl072209h",

language = "English (US)",

volume = "7",

pages = "3759--65",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors

AU - Choi, Mi-Ran

AU - Stanton-Maxey, Katie J

AU - Stanley, Jennifer K

AU - Levin, Carly S

AU - Bardhan, Rizia

AU - Akin, Demir

AU - Badve, Sunil

AU - Sturgis, Jennifer E.

AU - Robinson, J Paul

AU - Bashir, Rashid

AU - Halas, Naomi J.

AU - Clare, Susan E

PY - 2007/12

Y1 - 2007/12

N2 - Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

AB - Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

KW - Antineoplastic Agents

KW - Biological Transport

KW - Cell Hypoxia

KW - Drug Delivery Systems

KW - Humans

KW - Macrophages

KW - Monocytes

KW - Nanoparticles

KW - Neoplasms

KW - Spectrophotometry

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, Non-P.H.S.

U2 - 10.1021/nl072209h

DO - 10.1021/nl072209h

M3 - Article

C2 - 17979310

SN - 1530-6984

VL - 7

SP - 3759

EP - 3765

JO - Nano Letters

JF - Nano Letters

IS - 12

ER -

A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors

Abstract

Keywords

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