A role for K(ATP)/+-channels in mediating the elevations of cerebral blood flow and arterial pressure by hypoxic stimulation of oxygen-sensitive neurons of rostral ventrolateral medulla

Eugene V. Golanov; Donald J. Reis

doi:10.1016/S0006-8993(99)01256-1

A role for K(ATP)/⁺-channels in mediating the elevations of cerebral blood flow and arterial pressure by hypoxic stimulation of oxygen-sensitive neurons of rostral ventrolateral medulla

Eugene V. Golanov, Donald J. Reis

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Reticulospinal sympathoexcitatory neurons of rostral ventrolateral medulla (RVL) are selectively excited by hypoxia to elevate arterial pressure (AP) and cerebral blood flow (rCBF), that are elements of the oxygen- conserving (diving) reflex. We investigated whether K(ATP)/⁺-channels participate in this. Tolbutamide and glibenclamide, K(ATP)/⁺-channel blockers, microinjected into RVL in anesthetized rats, dose-dependently and site-specifically elevated AP and rCBF and potentiated responses to hypoxemia. K(ATP)/⁺-channels may mediate hypoxic excitation of oxygen- sensing RVL neurons.

Original language	English (US)
Pages (from-to)	210-214
Number of pages	5
Journal	Brain Research
Volume	827
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(99)01256-1
State	Published - May 8 1999

Keywords

Arterial pressure
ATP-sensitive potassium channel
Cerebral blood flow
Hypoxia
Oxygen
Rostral ventrolateral medulla

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology
Developmental Biology
Molecular Biology

Access to Document

10.1016/S0006-8993(99)01256-1

Cite this

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title = "A role for K(ATP)/+-channels in mediating the elevations of cerebral blood flow and arterial pressure by hypoxic stimulation of oxygen-sensitive neurons of rostral ventrolateral medulla",

abstract = "Reticulospinal sympathoexcitatory neurons of rostral ventrolateral medulla (RVL) are selectively excited by hypoxia to elevate arterial pressure (AP) and cerebral blood flow (rCBF), that are elements of the oxygen- conserving (diving) reflex. We investigated whether K(ATP)/+-channels participate in this. Tolbutamide and glibenclamide, K(ATP)/+-channel blockers, microinjected into RVL in anesthetized rats, dose-dependently and site-specifically elevated AP and rCBF and potentiated responses to hypoxemia. K(ATP)/+-channels may mediate hypoxic excitation of oxygen- sensing RVL neurons.",

keywords = "Arterial pressure, ATP-sensitive potassium channel, Cerebral blood flow, Hypoxia, Oxygen, Rostral ventrolateral medulla",

author = "Golanov, {Eugene V.} and Reis, {Donald J.}",

note = "Funding Information: This work was supported by NIH grants HL18974 and NS36154. ",

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AU - Golanov, Eugene V.

AU - Reis, Donald J.

N1 - Funding Information: This work was supported by NIH grants HL18974 and NS36154.

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AB - Reticulospinal sympathoexcitatory neurons of rostral ventrolateral medulla (RVL) are selectively excited by hypoxia to elevate arterial pressure (AP) and cerebral blood flow (rCBF), that are elements of the oxygen- conserving (diving) reflex. We investigated whether K(ATP)/+-channels participate in this. Tolbutamide and glibenclamide, K(ATP)/+-channel blockers, microinjected into RVL in anesthetized rats, dose-dependently and site-specifically elevated AP and rCBF and potentiated responses to hypoxemia. K(ATP)/+-channels may mediate hypoxic excitation of oxygen- sensing RVL neurons.

KW - Arterial pressure

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KW - Rostral ventrolateral medulla

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