A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP

Gina M. Doody; Louis B. Justement; Catherine C. Delibrias; R. James Matthews; Jiejian Lin; Matthew L. Thomas; Douglas T. Fearon

doi:10.1126/science.7618087

A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP

Gina M. Doody, Louis B. Justement, Catherine C. Delibrias, R. James Matthews, Jiejian Lin, Matthew L. Thomas, Douglas T. Fearon

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493 Scopus citations

Abstract

CD22 is a membrane immunoglobulin (mlg)-associated protein of B cells. CD22 is tyrosine-phosphorylated when mlg is ligated. Tyrosine-phosphorylated CD22 binds and activates SHP, a protein tyrosine phosphatase known to negatively regulate signaling through mlg. Ligation of CD22 to prevent its coaggregation with mlg lowers the threshold at which mlg activates the B cell by a factor of 100. In secondary lymphoid organs, CD22 may be sequestered away from mlg through interactions with counterreceptors on T cells. Thus, CD22 is a molecular switch for SHP that may bias mlg signaling to anatomic sites rich in T cells.

Original language	English (US)
Pages (from-to)	242-244
Number of pages	3
Journal	Science
Volume	269
Issue number	5221
DOIs	https://doi.org/10.1126/science.7618087
State	Published - 1995

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title = "A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP",

abstract = "CD22 is a membrane immunoglobulin (mlg)-associated protein of B cells. CD22 is tyrosine-phosphorylated when mlg is ligated. Tyrosine-phosphorylated CD22 binds and activates SHP, a protein tyrosine phosphatase known to negatively regulate signaling through mlg. Ligation of CD22 to prevent its coaggregation with mlg lowers the threshold at which mlg activates the B cell by a factor of 100. In secondary lymphoid organs, CD22 may be sequestered away from mlg through interactions with counterreceptors on T cells. Thus, CD22 is a molecular switch for SHP that may bias mlg signaling to anatomic sites rich in T cells.",

author = "Doody, {Gina M.} and Justement, {Louis B.} and Delibrias, {Catherine C.} and Matthews, {R. James} and Jiejian Lin and Thomas, {Matthew L.} and Fearon, {Douglas T.}",

year = "1995",

doi = "10.1126/science.7618087",

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volume = "269",

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T1 - A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP

AU - Doody, Gina M.

AU - Justement, Louis B.

AU - Delibrias, Catherine C.

AU - Matthews, R. James

AU - Lin, Jiejian

AU - Thomas, Matthew L.

AU - Fearon, Douglas T.

PY - 1995

Y1 - 1995

N2 - CD22 is a membrane immunoglobulin (mlg)-associated protein of B cells. CD22 is tyrosine-phosphorylated when mlg is ligated. Tyrosine-phosphorylated CD22 binds and activates SHP, a protein tyrosine phosphatase known to negatively regulate signaling through mlg. Ligation of CD22 to prevent its coaggregation with mlg lowers the threshold at which mlg activates the B cell by a factor of 100. In secondary lymphoid organs, CD22 may be sequestered away from mlg through interactions with counterreceptors on T cells. Thus, CD22 is a molecular switch for SHP that may bias mlg signaling to anatomic sites rich in T cells.

AB - CD22 is a membrane immunoglobulin (mlg)-associated protein of B cells. CD22 is tyrosine-phosphorylated when mlg is ligated. Tyrosine-phosphorylated CD22 binds and activates SHP, a protein tyrosine phosphatase known to negatively regulate signaling through mlg. Ligation of CD22 to prevent its coaggregation with mlg lowers the threshold at which mlg activates the B cell by a factor of 100. In secondary lymphoid organs, CD22 may be sequestered away from mlg through interactions with counterreceptors on T cells. Thus, CD22 is a molecular switch for SHP that may bias mlg signaling to anatomic sites rich in T cells.

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ER -

A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP

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