Abnormal response to IL-5 in B-cell chronic lymphocytic leukemia

Teresa G. Hayes; Xiao Lin Tan; Annemarie B. Moseley; Marilyn M. Huston; David P. Huston

doi:10.1016/0145-2126(93)90112-X

Abnormal response to IL-5 in B-cell chronic lymphocytic leukemia

Teresa G. Hayes, Xiao Lin Tan, Annemarie B. Moseley, Marilyn M. Huston, David P. Huston

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In B-cell chronic lymphocytic leukemia, neoplastic B-lymphocytes are arrested in development. Since interleukins are essential for B-cell differentiation, we examined whether B-CLL cells were capable of responding normally to interleukins. Purified B-lymphocytes from B-CLL patients and controls were compared for their ability to proliferate and differentiate after stimulation with MCAT or SAC plus rhIL-2 or rhIL-5. When rhIL-5 was added to MCAT-stimulated cells, 8 of 10 controls showed a substantial increase in IgM production, compared with only 1 of 10 B-CLL patients. Lack of IL-5 responsiveness could provide insight into the arrested B-lymphocyte development of some B-CLL patients.

Original language	English (US)
Pages (from-to)	777-783
Number of pages	7
Journal	Leukemia Research
Volume	17
Issue number	9
DOIs	https://doi.org/10.1016/0145-2126(93)90112-X
State	Published - Sep 1993

Keywords

B-CLL
B-lymphocyte differentiation
IL-2
IL-5
MCAT
SAC

ASJC Scopus subject areas

Oncology
Hematology
Cancer Research

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10.1016/0145-2126(93)90112-X

Cite this

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title = "Abnormal response to IL-5 in B-cell chronic lymphocytic leukemia",

abstract = "In B-cell chronic lymphocytic leukemia, neoplastic B-lymphocytes are arrested in development. Since interleukins are essential for B-cell differentiation, we examined whether B-CLL cells were capable of responding normally to interleukins. Purified B-lymphocytes from B-CLL patients and controls were compared for their ability to proliferate and differentiate after stimulation with MCAT or SAC plus rhIL-2 or rhIL-5. When rhIL-5 was added to MCAT-stimulated cells, 8 of 10 controls showed a substantial increase in IgM production, compared with only 1 of 10 B-CLL patients. Lack of IL-5 responsiveness could provide insight into the arrested B-lymphocyte development of some B-CLL patients.",

keywords = "B-CLL, B-lymphocyte differentiation, IL-2, IL-5, MCAT, SAC",

author = "Hayes, {Teresa G.} and Tan, {Xiao Lin} and Moseley, {Annemarie B.} and Huston, {Marilyn M.} and Huston, {David P.}",

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T1 - Abnormal response to IL-5 in B-cell chronic lymphocytic leukemia

AU - Hayes, Teresa G.

AU - Tan, Xiao Lin

AU - Moseley, Annemarie B.

AU - Huston, Marilyn M.

AU - Huston, David P.

PY - 1993/9

Y1 - 1993/9

N2 - In B-cell chronic lymphocytic leukemia, neoplastic B-lymphocytes are arrested in development. Since interleukins are essential for B-cell differentiation, we examined whether B-CLL cells were capable of responding normally to interleukins. Purified B-lymphocytes from B-CLL patients and controls were compared for their ability to proliferate and differentiate after stimulation with MCAT or SAC plus rhIL-2 or rhIL-5. When rhIL-5 was added to MCAT-stimulated cells, 8 of 10 controls showed a substantial increase in IgM production, compared with only 1 of 10 B-CLL patients. Lack of IL-5 responsiveness could provide insight into the arrested B-lymphocyte development of some B-CLL patients.

AB - In B-cell chronic lymphocytic leukemia, neoplastic B-lymphocytes are arrested in development. Since interleukins are essential for B-cell differentiation, we examined whether B-CLL cells were capable of responding normally to interleukins. Purified B-lymphocytes from B-CLL patients and controls were compared for their ability to proliferate and differentiate after stimulation with MCAT or SAC plus rhIL-2 or rhIL-5. When rhIL-5 was added to MCAT-stimulated cells, 8 of 10 controls showed a substantial increase in IgM production, compared with only 1 of 10 B-CLL patients. Lack of IL-5 responsiveness could provide insight into the arrested B-lymphocyte development of some B-CLL patients.

KW - B-CLL

KW - B-lymphocyte differentiation

KW - IL-2

KW - IL-5

KW - MCAT

KW - SAC

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Abnormal response to IL-5 in B-cell chronic lymphocytic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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