Acetaminophen hepatotoxicity and acute liver failure

Linda J. Chun; Myron J. Tong; Ronald W. Busuttil; Jonathan R. Hiatt

doi:10.1097/MCG.0b013e31818a3854

Acetaminophen hepatotoxicity and acute liver failure

Linda J. Chun, Myron J. Tong, Ronald W. Busuttil, Jonathan R. Hiatt

Research output: Contribution to journal › Review article › peer-review

265 Scopus citations

Abstract

Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most common cause of ALF in both United States and United Kingdom, with a trend to increasing incidence in the United States. N-acetylcysteine is the most effective drug to prevent progression to liver failure with acetaminophen hepatotoxicity. Liver transplantation is the only definitive therapy that will significantly increase the chances of survival for advanced ALF. This communication reviews current information regarding causes and management of acetaminophen-induced hepatotoxicity and ALF.

Original language	English (US)
Pages (from-to)	342-349
Number of pages	8
Journal	Journal of Clinical Gastroenterology
Volume	43
Issue number	4
DOIs	https://doi.org/10.1097/MCG.0b013e31818a3854
State	Published - Apr 2009

Keywords

Acute liver failure
Drug toxicity
Liver transplantation

ASJC Scopus subject areas

Gastroenterology

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10.1097/MCG.0b013e31818a3854

Cite this

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title = "Acetaminophen hepatotoxicity and acute liver failure",

abstract = "Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most common cause of ALF in both United States and United Kingdom, with a trend to increasing incidence in the United States. N-acetylcysteine is the most effective drug to prevent progression to liver failure with acetaminophen hepatotoxicity. Liver transplantation is the only definitive therapy that will significantly increase the chances of survival for advanced ALF. This communication reviews current information regarding causes and management of acetaminophen-induced hepatotoxicity and ALF.",

keywords = "Acute liver failure, Drug toxicity, Liver transplantation",

author = "Chun, {Linda J.} and Tong, {Myron J.} and Busuttil, {Ronald W.} and Hiatt, {Jonathan R.}",

year = "2009",

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language = "English (US)",

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T1 - Acetaminophen hepatotoxicity and acute liver failure

AU - Chun, Linda J.

AU - Tong, Myron J.

AU - Busuttil, Ronald W.

AU - Hiatt, Jonathan R.

PY - 2009/4

Y1 - 2009/4

N2 - Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most common cause of ALF in both United States and United Kingdom, with a trend to increasing incidence in the United States. N-acetylcysteine is the most effective drug to prevent progression to liver failure with acetaminophen hepatotoxicity. Liver transplantation is the only definitive therapy that will significantly increase the chances of survival for advanced ALF. This communication reviews current information regarding causes and management of acetaminophen-induced hepatotoxicity and ALF.

AB - Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most common cause of ALF in both United States and United Kingdom, with a trend to increasing incidence in the United States. N-acetylcysteine is the most effective drug to prevent progression to liver failure with acetaminophen hepatotoxicity. Liver transplantation is the only definitive therapy that will significantly increase the chances of survival for advanced ALF. This communication reviews current information regarding causes and management of acetaminophen-induced hepatotoxicity and ALF.

KW - Acute liver failure

KW - Drug toxicity

KW - Liver transplantation

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DO - 10.1097/MCG.0b013e31818a3854

M3 - Review article

C2 - 19169150

AN - SCOPUS:65549144282

SN - 0192-0790

VL - 43

SP - 342

EP - 349

JO - Journal of Clinical Gastroenterology

JF - Journal of Clinical Gastroenterology

IS - 4

ER -

Acetaminophen hepatotoxicity and acute liver failure

Abstract

Keywords

ASJC Scopus subject areas

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