Activation of the hedgehog pathway in a subset of lung cancers

Sumin Chi; Shuhong Huang; Chengxin Li; Xiaoli Zhang; Nonggao He; Manoop S. Bhutani; Dennie Jones; Claudia Y. Castro; Roberto Logrono; Abida Haque; Joseph Zwischenberger; Stephen K. Tyring; Hongwei Zhang; Jingwu Xie

doi:10.1016/j.canlet.2005.11.036

Activation of the hedgehog pathway in a subset of lung cancers

Sumin Chi, Shuhong Huang, Chengxin Li, Xiaoli Zhang, Nonggao He, Manoop S. Bhutani, Dennie Jones, Claudia Y. Castro, Roberto Logrono, Abida Haque, Joseph Zwischenberger, Stephen K. Tyring, Hongwei Zhang, Jingwu Xie

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Activation of the hedgehog pathway is reported in lung cancer, but its frequency remains unknown. We examine activation of this pathway in lung cancers by in situ hybridization and immunohistochemstry, and find that less than 10% of the tumors have elevated hedgehog target gene expression. We further identify a cell line NCI-H209 and two primary tumors with no detectable Su(Fu), a negative regulator of the pathway. Ectopic expression of Su(Fu) in NCI-H209 cells down-regulates hedgehog target gene expression and leads to inhibition of cell proliferation. These data indicate that activation of the hedgehog pathway is activated through Shh over-expression or Su(Fu) inactivation in only a subset of lung cancers.

Original language	English (US)
Pages (from-to)	53-60
Number of pages	8
Journal	Cancer Letters
Volume	244
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2005.11.036
State	Published - Nov 28 2006

Keywords

Gli1
Hedgehog
Lung cancer
PTCH1
Su(Fu)

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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10.1016/j.canlet.2005.11.036

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title = "Activation of the hedgehog pathway in a subset of lung cancers",

abstract = "Activation of the hedgehog pathway is reported in lung cancer, but its frequency remains unknown. We examine activation of this pathway in lung cancers by in situ hybridization and immunohistochemstry, and find that less than 10% of the tumors have elevated hedgehog target gene expression. We further identify a cell line NCI-H209 and two primary tumors with no detectable Su(Fu), a negative regulator of the pathway. Ectopic expression of Su(Fu) in NCI-H209 cells down-regulates hedgehog target gene expression and leads to inhibition of cell proliferation. These data indicate that activation of the hedgehog pathway is activated through Shh over-expression or Su(Fu) inactivation in only a subset of lung cancers.",

keywords = "Gli1, Hedgehog, Lung cancer, PTCH1, Su(Fu)",

author = "Sumin Chi and Shuhong Huang and Chengxin Li and Xiaoli Zhang and Nonggao He and Bhutani, {Manoop S.} and Dennie Jones and Castro, {Claudia Y.} and Roberto Logrono and Abida Haque and Joseph Zwischenberger and Tyring, {Stephen K.} and Hongwei Zhang and Jingwu Xie",

note = "Funding Information: This research was supported by grants from the NIH (R01-CA94160, JX), Department of Defense (DOD-PC030429, JX), the NIEHS (ES06676) and National Science Foundation of China (30228031, JX and HWZ). ",

year = "2006",

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day = "28",

doi = "10.1016/j.canlet.2005.11.036",

language = "English (US)",

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AU - Chi, Sumin

AU - Huang, Shuhong

AU - Li, Chengxin

AU - Zhang, Xiaoli

AU - He, Nonggao

AU - Bhutani, Manoop S.

AU - Jones, Dennie

AU - Castro, Claudia Y.

AU - Logrono, Roberto

AU - Haque, Abida

AU - Zwischenberger, Joseph

AU - Tyring, Stephen K.

AU - Zhang, Hongwei

AU - Xie, Jingwu

N1 - Funding Information: This research was supported by grants from the NIH (R01-CA94160, JX), Department of Defense (DOD-PC030429, JX), the NIEHS (ES06676) and National Science Foundation of China (30228031, JX and HWZ).

PY - 2006/11/28

Y1 - 2006/11/28

N2 - Activation of the hedgehog pathway is reported in lung cancer, but its frequency remains unknown. We examine activation of this pathway in lung cancers by in situ hybridization and immunohistochemstry, and find that less than 10% of the tumors have elevated hedgehog target gene expression. We further identify a cell line NCI-H209 and two primary tumors with no detectable Su(Fu), a negative regulator of the pathway. Ectopic expression of Su(Fu) in NCI-H209 cells down-regulates hedgehog target gene expression and leads to inhibition of cell proliferation. These data indicate that activation of the hedgehog pathway is activated through Shh over-expression or Su(Fu) inactivation in only a subset of lung cancers.

AB - Activation of the hedgehog pathway is reported in lung cancer, but its frequency remains unknown. We examine activation of this pathway in lung cancers by in situ hybridization and immunohistochemstry, and find that less than 10% of the tumors have elevated hedgehog target gene expression. We further identify a cell line NCI-H209 and two primary tumors with no detectable Su(Fu), a negative regulator of the pathway. Ectopic expression of Su(Fu) in NCI-H209 cells down-regulates hedgehog target gene expression and leads to inhibition of cell proliferation. These data indicate that activation of the hedgehog pathway is activated through Shh over-expression or Su(Fu) inactivation in only a subset of lung cancers.

KW - Gli1

KW - Hedgehog

KW - Lung cancer

KW - PTCH1

KW - Su(Fu)

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Activation of the hedgehog pathway in a subset of lung cancers

Abstract

Keywords

ASJC Scopus subject areas

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