Acute retinal necrosis associated with epstein-barr virus: Immunohistopathologic confirmation

Shlomit Schaal; Aleksandr Kagan; Yujuan Wang; Chi Chao Chan; Henry J. Kaplan

doi:10.1001/jamaophthalmol.2014.266

Acute retinal necrosis associated with epstein-barr virus: Immunohistopathologic confirmation

Shlomit Schaal, Aleksandr Kagan, Yujuan Wang, Chi Chao Chan, Henry J. Kaplan

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

IMPORTANCE: Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation.We report the clinical history and histopathologic confirmation that EBV can cause ARN. OBSERVATIONS: Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology. CONCLUSIONS AND RELEVANCE: Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.

Original language	English (US)
Pages (from-to)	881-882
Number of pages	2
Journal	JAMA Ophthalmology
Volume	132
Issue number	7
DOIs	https://doi.org/10.1001/jamaophthalmol.2014.266
State	Published - Jul 2014

ASJC Scopus subject areas

Ophthalmology

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title = "Acute retinal necrosis associated with epstein-barr virus: Immunohistopathologic confirmation",

abstract = "IMPORTANCE: Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation.We report the clinical history and histopathologic confirmation that EBV can cause ARN. OBSERVATIONS: Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology. CONCLUSIONS AND RELEVANCE: Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.",

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T1 - Acute retinal necrosis associated with epstein-barr virus

T2 - Immunohistopathologic confirmation

AU - Schaal, Shlomit

AU - Kagan, Aleksandr

AU - Wang, Yujuan

AU - Chan, Chi Chao

AU - Kaplan, Henry J.

PY - 2014/7

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AB - IMPORTANCE: Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation.We report the clinical history and histopathologic confirmation that EBV can cause ARN. OBSERVATIONS: Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology. CONCLUSIONS AND RELEVANCE: Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.

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Acute retinal necrosis associated with epstein-barr virus: Immunohistopathologic confirmation

Abstract

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