Adoptive cellular immunotherapy for viral diseases

Y. Fujita; C. M. Rooney; H. E. Heslop

doi:10.1038/sj.bmt.1705906

Adoptive cellular immunotherapy for viral diseases

Y. Fujita, C. M. Rooney, H. E. Heslop

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

Viral infections remain a major cause of morbidity and mortality after pediatric hematopoietic stem cell transplantation. Adoptive transfer of donor-derived virus-specific T cells can reconstitute antiviral immunity in recipients and be effective both in preventing and treating cytomegalovirus, Epstein-Barr virus and adenovirus infection. Current efforts are focused on providing protection toward a broader range of viruses safely, rapidly and effectively.

Original language	English (US)
Pages (from-to)	193-198
Number of pages	6
Journal	Bone Marrow Transplantation
Volume	41
Issue number	2
DOIs	https://doi.org/10.1038/sj.bmt.1705906
State	Published - Jan 2008

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1705906

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title = "Adoptive cellular immunotherapy for viral diseases",

abstract = "Viral infections remain a major cause of morbidity and mortality after pediatric hematopoietic stem cell transplantation. Adoptive transfer of donor-derived virus-specific T cells can reconstitute antiviral immunity in recipients and be effective both in preventing and treating cytomegalovirus, Epstein-Barr virus and adenovirus infection. Current efforts are focused on providing protection toward a broader range of viruses safely, rapidly and effectively.",

author = "Y. Fujita and Rooney, {C. M.} and Heslop, {H. E.}",

note = "Funding Information: This work was supported by NIH Grants PO1 CA94237, U54HL081007, the GCRC at Baylor College of Medicine (RR00188), and a Specialized Center of Research Award from the Leukemia Lymphoma Society, and a Doris Duke Distinguished Clinical Scientist Award to HEH.",

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AU - Rooney, C. M.

AU - Heslop, H. E.

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N2 - Viral infections remain a major cause of morbidity and mortality after pediatric hematopoietic stem cell transplantation. Adoptive transfer of donor-derived virus-specific T cells can reconstitute antiviral immunity in recipients and be effective both in preventing and treating cytomegalovirus, Epstein-Barr virus and adenovirus infection. Current efforts are focused on providing protection toward a broader range of viruses safely, rapidly and effectively.

AB - Viral infections remain a major cause of morbidity and mortality after pediatric hematopoietic stem cell transplantation. Adoptive transfer of donor-derived virus-specific T cells can reconstitute antiviral immunity in recipients and be effective both in preventing and treating cytomegalovirus, Epstein-Barr virus and adenovirus infection. Current efforts are focused on providing protection toward a broader range of viruses safely, rapidly and effectively.

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Adoptive cellular immunotherapy for viral diseases

Abstract

ASJC Scopus subject areas

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