TY - JOUR
T1 - Adult Stem Cells for Bone Regeneration and Repair
AU - Iaquinta, Maria Rosa
AU - Mazzoni, Elisa
AU - Bononi, Ilaria
AU - Rotondo, John Charles
AU - Mazziotta, Chiara
AU - Montesi, Monica
AU - Sprio, Simone
AU - Tampieri, Anna
AU - Tognon, Mauro
AU - Martini, Fernanda
N1 - Copyright © 2019 Iaquinta, Mazzoni, Bononi, Rotondo, Mazziotta, Montesi, Sprio, Tampieri, Tognon and Martini.
PY - 2019/11/12
Y1 - 2019/11/12
N2 - The regeneration of bone fractures, resulting from trauma, osteoporosis or tumors, is a major problem in our super-aging society. Bone regeneration is one of the main topics of concern in regenerative medicine. In recent years, stem cells have been employed in regenerative medicine with interesting results due to their self-renewal and differentiation capacity. Moreover, stem cells are able to secrete bioactive molecules and regulate the behavior of other cells in different host tissues. Bone regeneration process may improve effectively and rapidly when stem cells are used. To this purpose, stem cells are often employed with biomaterials/scaffolds and growth factors to accelerate bone healing at the fracture site. Briefly, this review will describe bone structure and the osteogenic differentiation of stem cells. In addition, the role of mesenchymal stem cells for bone repair/regrowth in the tissue engineering field and their recent progress in clinical applications will be discussed.
AB - The regeneration of bone fractures, resulting from trauma, osteoporosis or tumors, is a major problem in our super-aging society. Bone regeneration is one of the main topics of concern in regenerative medicine. In recent years, stem cells have been employed in regenerative medicine with interesting results due to their self-renewal and differentiation capacity. Moreover, stem cells are able to secrete bioactive molecules and regulate the behavior of other cells in different host tissues. Bone regeneration process may improve effectively and rapidly when stem cells are used. To this purpose, stem cells are often employed with biomaterials/scaffolds and growth factors to accelerate bone healing at the fracture site. Briefly, this review will describe bone structure and the osteogenic differentiation of stem cells. In addition, the role of mesenchymal stem cells for bone repair/regrowth in the tissue engineering field and their recent progress in clinical applications will be discussed.
KW - bone
KW - differentiation
KW - regenerative medicine
KW - repair
KW - stem cell
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U2 - 10.3389/fcell.2019.00268
DO - 10.3389/fcell.2019.00268
M3 - Review article
AN - SCOPUS:85075829745
SN - 2296-634X
VL - 7
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
M1 - 268
ER -