Abstract
Cancer is one of the leading causes of death globally. A variety of phenolic compounds display preventative and therapeutic effects against cancers. Green teas are rich in phenolics. Catechins are the most dominant phenolic component in green teas. Studies have shown that catechins have anticancer activity in various cancer models. The anticancer activity of catechins, however, may be compromised due to their low oral bioavailability. Nanodelivery emerges as a promising way to improve the oral bioavailability and anticancer activity of catechins. Research in this area has been actively conducted in recent decades. This review provides the molecular mechanisms of the anticancer effects of catechins, the factors that limit the oral bioavailability of catechins, and the latest advances of delivering catechins using nanodelivery systems through different routes to enhance their anticancer activity.
| Original language | English (US) |
|---|---|
| Article number | 3301 |
| Journal | Molecules |
| Volume | 26 |
| Issue number | 11 |
| DOIs | |
| State | Published - May 31 2021 |
Keywords
- Anticancer activity
- Catechins
- Green tea
- Nanodelivery system
- Phenolic compounds
- Cell Proliferation
- Humans
- Lipids/chemistry
- Cell Cycle/drug effects
- Drug Carriers
- Drug Delivery Systems
- Antineoplastic Agents/pharmacology
- Catechin/chemistry
- Gastrointestinal Microbiome/drug effects
- Anti-Infective Agents/pharmacology
- Antioxidants/pharmacology
- Administration, Oral
- Neoplasms/drug therapy
- Anti-Inflammatory Agents/pharmacology
- Nanomedicine/methods
- Neoplasm Metastasis/drug therapy
- Tea
- Animals
- Mice
- Phenol/chemistry
ASJC Scopus subject areas
- Drug Discovery
- Analytical Chemistry
- Chemistry (miscellaneous)
- Molecular Medicine
- Physical and Theoretical Chemistry
- Pharmaceutical Science
- Organic Chemistry