TY - JOUR
T1 - Advances in Skin-on-a-Chip Technologies for Dermatological Disease Modeling
AU - Cho, Seo Won
AU - Malick, Hamza
AU - Kim, Soo Jung
AU - Grattoni, Alessandro
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024
Y1 - 2024
N2 - Skin-on-a-chip (SoC) technologies are emerging as a paradigm shift in dermatology research by replicating human physiology in a dynamic manner not achievable by current animal models. Although animal models have contributed to successful clinical trials, their ability to predict human outcomes remains questionable, owing to inherent differences in skin anatomy and immune response. Covering areas including infectious diseases, autoimmune skin conditions, wound healing, drug toxicity, aging, and antiaging, SoC aims to circumvent the inherent disparities created by traditional models. In this paper, we review current SoC technologies, highlighting their potential as an alternative to animal models for a deeper understanding of complex skin conditions.
AB - Skin-on-a-chip (SoC) technologies are emerging as a paradigm shift in dermatology research by replicating human physiology in a dynamic manner not achievable by current animal models. Although animal models have contributed to successful clinical trials, their ability to predict human outcomes remains questionable, owing to inherent differences in skin anatomy and immune response. Covering areas including infectious diseases, autoimmune skin conditions, wound healing, drug toxicity, aging, and antiaging, SoC aims to circumvent the inherent disparities created by traditional models. In this paper, we review current SoC technologies, highlighting their potential as an alternative to animal models for a deeper understanding of complex skin conditions.
KW - Dermatology
KW - In vitro disease models
KW - Lab on a chip
KW - Microfluidics
KW - Skin grafts
KW - Tissue-on-a-chip
UR - http://www.scopus.com/inward/record.url?scp=85187993641&partnerID=8YFLogxK
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U2 - 10.1016/j.jid.2024.01.031
DO - 10.1016/j.jid.2024.01.031
M3 - Review article
C2 - 38493383
AN - SCOPUS:85187993641
SN - 0022-202X
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
ER -