Age-related changes in HSP25 expression in basal ganglia and cortex of F344/BN rats

Anisha A. Gupte; Jill K. Morris; Hongyu Zhang; Gregory L. Bomhoff; Paige C. Geiger; John A. Stanford

doi:10.1016/j.neulet.2010.01.049

Age-related changes in HSP25 expression in basal ganglia and cortex of F344/BN rats

Anisha A. Gupte, Jill K. Morris, Hongyu Zhang, Gregory L. Bomhoff, Paige C. Geiger, John A. Stanford

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Normal aging is associated with chronic oxidative stress. In the basal ganglia, oxidative stress may contribute to the increased risk of Parkinson's disease in the elderly. Neurons are thought to actively utilize compensatory defense mechanisms, such as heat shock proteins (HSPs), to protect from persisting stress. Despite their protective role, little is known about HSP expression in the aging basal ganglia. The purpose of this study was to examine HSP expression in striatum, substantia nigra, globus pallidus and cortex in 6-, 18- and 30-month-old Fischer 344/Brown Norway rats. We found robust age-related increases in phosphorylated and total HSP25 in each brain region studied. Conversely, HSP72 (the inducible form of HSP70) was reduced with age, but only in the striatum. p38 MAPK, a protein implicated in activating HSP25, did not change with age, nor did HSC70 (the constitutive form of HSP70), or HSP60. These results suggest that HSP25 is especially responsive to age-related stress in the basal ganglia.

Original language	English (US)
Pages (from-to)	90-93
Number of pages	4
Journal	Neuroscience Letters
Volume	472
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2010.01.049
State	Published - Mar 19 2010

Keywords

Aging
Basal ganglia
Chaperones
Heat shock
Neuroprotection
Parkinsonism
Stress

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2010.01.049

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title = "Age-related changes in HSP25 expression in basal ganglia and cortex of F344/BN rats",

abstract = "Normal aging is associated with chronic oxidative stress. In the basal ganglia, oxidative stress may contribute to the increased risk of Parkinson's disease in the elderly. Neurons are thought to actively utilize compensatory defense mechanisms, such as heat shock proteins (HSPs), to protect from persisting stress. Despite their protective role, little is known about HSP expression in the aging basal ganglia. The purpose of this study was to examine HSP expression in striatum, substantia nigra, globus pallidus and cortex in 6-, 18- and 30-month-old Fischer 344/Brown Norway rats. We found robust age-related increases in phosphorylated and total HSP25 in each brain region studied. Conversely, HSP72 (the inducible form of HSP70) was reduced with age, but only in the striatum. p38 MAPK, a protein implicated in activating HSP25, did not change with age, nor did HSC70 (the constitutive form of HSP70), or HSP60. These results suggest that HSP25 is especially responsive to age-related stress in the basal ganglia.",

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AU - Morris, Jill K.

AU - Zhang, Hongyu

AU - Bomhoff, Gregory L.

AU - Geiger, Paige C.

AU - Stanford, John A.

PY - 2010/3/19

Y1 - 2010/3/19

N2 - Normal aging is associated with chronic oxidative stress. In the basal ganglia, oxidative stress may contribute to the increased risk of Parkinson's disease in the elderly. Neurons are thought to actively utilize compensatory defense mechanisms, such as heat shock proteins (HSPs), to protect from persisting stress. Despite their protective role, little is known about HSP expression in the aging basal ganglia. The purpose of this study was to examine HSP expression in striatum, substantia nigra, globus pallidus and cortex in 6-, 18- and 30-month-old Fischer 344/Brown Norway rats. We found robust age-related increases in phosphorylated and total HSP25 in each brain region studied. Conversely, HSP72 (the inducible form of HSP70) was reduced with age, but only in the striatum. p38 MAPK, a protein implicated in activating HSP25, did not change with age, nor did HSC70 (the constitutive form of HSP70), or HSP60. These results suggest that HSP25 is especially responsive to age-related stress in the basal ganglia.

AB - Normal aging is associated with chronic oxidative stress. In the basal ganglia, oxidative stress may contribute to the increased risk of Parkinson's disease in the elderly. Neurons are thought to actively utilize compensatory defense mechanisms, such as heat shock proteins (HSPs), to protect from persisting stress. Despite their protective role, little is known about HSP expression in the aging basal ganglia. The purpose of this study was to examine HSP expression in striatum, substantia nigra, globus pallidus and cortex in 6-, 18- and 30-month-old Fischer 344/Brown Norway rats. We found robust age-related increases in phosphorylated and total HSP25 in each brain region studied. Conversely, HSP72 (the inducible form of HSP70) was reduced with age, but only in the striatum. p38 MAPK, a protein implicated in activating HSP25, did not change with age, nor did HSC70 (the constitutive form of HSP70), or HSP60. These results suggest that HSP25 is especially responsive to age-related stress in the basal ganglia.

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KW - Stress

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Age-related changes in HSP25 expression in basal ganglia and cortex of F344/BN rats

Abstract

Keywords

ASJC Scopus subject areas

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