TY - JOUR
T1 - Air pollution
T2 - A culprit of lung cancer
AU - Xue, Yueguang
AU - Wang, Liuxiang
AU - Zhang, Yiming
AU - Zhao, Yuliang
AU - Liu, Ying
N1 - Funding Information:
This work was financially supported by the Program for International S&T Cooperation Projects of the Ministry of Science and Technology of China (2018YFE0117200), National Natural Science Foundation of China ( 31971318 ), the Special Project for Research and Development in Key Areas of Guangdong Province ( 2020B0101020001 ), the Strategic Priority Research Program of Chinese Academy of Sciences ( XDB36000000 ).
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/7/15
Y1 - 2022/7/15
N2 - Air pollution is a global health problem, especially in the context of rapid economic development and the expansion of urbanization. Herein, we discuss the harmful effects of outdoor and indoor pollution on the lungs. Ambient particulate matters (PMs) from industrial and vehicle exhausts is associated with lung cancer. Workers exposed to asbestos, polycyclic aromatic hydrocarbons (PAHs), and toxic metals are also likely to develop lung cancer. Indoors, cooking fumes, second-hand smoke, and radioactive products from house decoration materials play roles in the development of lung cancer. Bacteria and viruses can also be detrimental to health and are important risk factors in lung inflammation and cancer. Specific effects of lung cancer caused by air pollution are discussed in detail, including inflammation, DNA damage, and epigenetic regulation. In addition, advanced materials for personal protection, as well as the current government policies to prevent air pollution, are summarized. This review provides a basis for future research on the relationship between lung cancer and air pollution.
AB - Air pollution is a global health problem, especially in the context of rapid economic development and the expansion of urbanization. Herein, we discuss the harmful effects of outdoor and indoor pollution on the lungs. Ambient particulate matters (PMs) from industrial and vehicle exhausts is associated with lung cancer. Workers exposed to asbestos, polycyclic aromatic hydrocarbons (PAHs), and toxic metals are also likely to develop lung cancer. Indoors, cooking fumes, second-hand smoke, and radioactive products from house decoration materials play roles in the development of lung cancer. Bacteria and viruses can also be detrimental to health and are important risk factors in lung inflammation and cancer. Specific effects of lung cancer caused by air pollution are discussed in detail, including inflammation, DNA damage, and epigenetic regulation. In addition, advanced materials for personal protection, as well as the current government policies to prevent air pollution, are summarized. This review provides a basis for future research on the relationship between lung cancer and air pollution.
KW - Air pollution
KW - Health
KW - Lung cancer
KW - Pathogenesis
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U2 - 10.1016/j.jhazmat.2022.128937
DO - 10.1016/j.jhazmat.2022.128937
M3 - Review article
C2 - 35452993
AN - SCOPUS:85128575091
SN - 0304-3894
VL - 434
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
M1 - 128937
ER -