TY - JOUR
T1 - Alcohol Toxicity in Diabetes and Its Complications
T2 - A Double Trouble?
AU - Munukutla, Srikar
AU - Pan, Guodong
AU - Deshpande, Mandar
AU - Thandavarayan, Rajarajan A.
AU - Krishnamurthy, Prasanna
AU - Palaniyandi, Suresh S.
N1 - Publisher Copyright:
© 2016 Research Society on Alcoholism.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Background: Eight percent of the U.S. population has been diagnosed with diabetes mellitus (DM), while another large percentage has gone undiagnosed. As the epidemiology of this disease constitutes a larger percentage of the American population, another factor presents a dangerous dilemma that can exacerbate the hazardous effects imposed by DM. Excessive alcohol consumption concerns the health of more than 50% of all adults. When this heavy-alcohol-drinking population overlaps with DM and its complications, the effects can be dangerous. In this review, we term it as "double trouble." Methods: We provide evidence of alcohol-induced exacerbation of organ damage in diabetic conditions. In certain cases, we have explained how diabetes and alcohol induce similar pathological effects. Results: Known exacerbated complications include those related to heart diseases, liver damage, kidney dysfunction, as well as retinal and neurological impairment. Often, pathophysiological damage concludes with end-stage disorders and even mortality. The metabolic, cell signaling, and pathophysiological changes associated with "double trouble" would lead to the identification of novel therapeutic targets. Conclusions: This review summarizes the epidemiology, diagnosis, pathophysiology, metabolic, and cell signaling alterations and finally brushes upon issues and strategies to manage the "double trouble".
AB - Background: Eight percent of the U.S. population has been diagnosed with diabetes mellitus (DM), while another large percentage has gone undiagnosed. As the epidemiology of this disease constitutes a larger percentage of the American population, another factor presents a dangerous dilemma that can exacerbate the hazardous effects imposed by DM. Excessive alcohol consumption concerns the health of more than 50% of all adults. When this heavy-alcohol-drinking population overlaps with DM and its complications, the effects can be dangerous. In this review, we term it as "double trouble." Methods: We provide evidence of alcohol-induced exacerbation of organ damage in diabetic conditions. In certain cases, we have explained how diabetes and alcohol induce similar pathological effects. Results: Known exacerbated complications include those related to heart diseases, liver damage, kidney dysfunction, as well as retinal and neurological impairment. Often, pathophysiological damage concludes with end-stage disorders and even mortality. The metabolic, cell signaling, and pathophysiological changes associated with "double trouble" would lead to the identification of novel therapeutic targets. Conclusions: This review summarizes the epidemiology, diagnosis, pathophysiology, metabolic, and cell signaling alterations and finally brushes upon issues and strategies to manage the "double trouble".
KW - Alcohol Toxicity
KW - Aldehyde Dehydrogenase
KW - Cell Signaling
KW - Diabetes Mellitus
KW - Epidemiology
KW - Mitochondrial Dysfunction
KW - Pathophysiology
UR - http://www.scopus.com/inward/record.url?scp=84961631736&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961631736&partnerID=8YFLogxK
U2 - 10.1111/acer.13008
DO - 10.1111/acer.13008
M3 - Review article
C2 - 27013182
AN - SCOPUS:84961631736
SN - 0145-6008
VL - 40
SP - 686
EP - 697
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
IS - 4
ER -