Abstract
The synthesis and release of 3H-acetylcholine was measured in hippocampal slices of adult rat brain following acute in vitro exposure to ethanolamine. Evoked release of 3H-acetylcholine was elevated by 60-70% but 3H-acetylcholine synthesis was unaffected. Other amino alcohols were also found to significantly increase evoked 3H-acetylcholine release. The effect may be stereochemically mediated since only one of four possible propanolamine configurations, R-alaninol, was active. The most potent compound tested was R-prolinol which showed an EC50 nearly 10-fold lower than that of either R-alaninol or ethanolamine; S-prolinol was inactive. Slices taken from adult rats which had been fed active compounds for two weeks also exhibited enhancements in evoked 3H-acetylcholine release. These results indicate that amino alcohols modulate acetylcholine release in the rat hippocampus.
Original language | English (US) |
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Pages (from-to) | 425-428 |
Number of pages | 4 |
Journal | NeuroReport |
Volume | 3 |
Issue number | 5 |
DOIs | |
State | Published - May 1992 |
Keywords
- Acetylcholine release
- Amino alcohol
- Ethanolamine
- Hippocampus
- Modulation
ASJC Scopus subject areas
- Neuroscience(all)