Amino and carboxyl plasma functionalization of collagen films for tissue engineering applications

F Taraballi; S Zanini; C Lupo; S Panseri; C Cunha; C Riccardi; M Marcacci; M Campione; L Cipolla

doi:10.1016/j.jcis.2012.11.041

Amino and carboxyl plasma functionalization of collagen films for tissue engineering applications

F Taraballi, S Zanini, C Lupo, S Panseri, C Cunha, C Riccardi, M Marcacci, M Campione, L Cipolla

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Type I collagen films have been functionalized on their surfaces by plasma treatment with carboxyl and amino groups to improve their potential for grafting bioactive molecules. The physico-chemical properties of the plasma-treated films were evaluated and compared to the untreated materials by water contact angle, SEM and AFM. The presence of new functional groups on the film surfaces has been assessed by ATR-FTIR spectra after chemical derivatization. Moreover, the biocompatibility of the plasma-treated films was studied with MG-63 human osteoblast-like cells, evaluating cell proliferation, viability and morphology at 1, 3 and 7 days.

Original language	English (US)
Pages (from-to)	590-7
Number of pages	8
Journal	Journal of Colloid And Interface Science
Volume	394
DOIs	https://doi.org/10.1016/j.jcis.2012.11.041
State	Published - Mar 15 2013

Keywords

Biocompatible Materials
Cell Adhesion
Cell Line
Cell Proliferation
Cell Survival
Collagen Type I
Humans
Materials Testing
Osteoblasts
Surface Properties
Tissue Engineering
Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.jcis.2012.11.041

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title = "Amino and carboxyl plasma functionalization of collagen films for tissue engineering applications",

abstract = "Type I collagen films have been functionalized on their surfaces by plasma treatment with carboxyl and amino groups to improve their potential for grafting bioactive molecules. The physico-chemical properties of the plasma-treated films were evaluated and compared to the untreated materials by water contact angle, SEM and AFM. The presence of new functional groups on the film surfaces has been assessed by ATR-FTIR spectra after chemical derivatization. Moreover, the biocompatibility of the plasma-treated films was studied with MG-63 human osteoblast-like cells, evaluating cell proliferation, viability and morphology at 1, 3 and 7 days.",

keywords = "Biocompatible Materials, Cell Adhesion, Cell Line, Cell Proliferation, Cell Survival, Collagen Type I, Humans, Materials Testing, Osteoblasts, Surface Properties, Tissue Engineering, Journal Article, Research Support, Non-U.S. Gov't",

author = "F Taraballi and S Zanini and C Lupo and S Panseri and C Cunha and C Riccardi and M Marcacci and M Campione and L Cipolla",

year = "2013",

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day = "15",

doi = "10.1016/j.jcis.2012.11.041",

language = "English (US)",

volume = "394",

pages = "590--7",

journal = "Journal of Colloid And Interface Science",

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publisher = "Academic Press",

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TY - JOUR

T1 - Amino and carboxyl plasma functionalization of collagen films for tissue engineering applications

AU - Taraballi, F

AU - Zanini, S

AU - Lupo, C

AU - Panseri, S

AU - Cunha, C

AU - Riccardi, C

AU - Marcacci, M

AU - Campione, M

AU - Cipolla, L

PY - 2013/3/15

Y1 - 2013/3/15

N2 - Type I collagen films have been functionalized on their surfaces by plasma treatment with carboxyl and amino groups to improve their potential for grafting bioactive molecules. The physico-chemical properties of the plasma-treated films were evaluated and compared to the untreated materials by water contact angle, SEM and AFM. The presence of new functional groups on the film surfaces has been assessed by ATR-FTIR spectra after chemical derivatization. Moreover, the biocompatibility of the plasma-treated films was studied with MG-63 human osteoblast-like cells, evaluating cell proliferation, viability and morphology at 1, 3 and 7 days.

AB - Type I collagen films have been functionalized on their surfaces by plasma treatment with carboxyl and amino groups to improve their potential for grafting bioactive molecules. The physico-chemical properties of the plasma-treated films were evaluated and compared to the untreated materials by water contact angle, SEM and AFM. The presence of new functional groups on the film surfaces has been assessed by ATR-FTIR spectra after chemical derivatization. Moreover, the biocompatibility of the plasma-treated films was studied with MG-63 human osteoblast-like cells, evaluating cell proliferation, viability and morphology at 1, 3 and 7 days.

KW - Biocompatible Materials

KW - Cell Adhesion

KW - Cell Line

KW - Cell Proliferation

KW - Cell Survival

KW - Collagen Type I

KW - Humans

KW - Materials Testing

KW - Osteoblasts

KW - Surface Properties

KW - Tissue Engineering

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.jcis.2012.11.041

DO - 10.1016/j.jcis.2012.11.041

M3 - Article

C2 - 23266023

SN - 0021-9797

VL - 394

SP - 590

EP - 597

JO - Journal of Colloid And Interface Science

JF - Journal of Colloid And Interface Science

ER -

Amino and carboxyl plasma functionalization of collagen films for tissue engineering applications

Abstract

Keywords

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