TY - JOUR
T1 - Amitriptyline normalizes tetrabenazine-induced changes in cerebral microcirculation
AU - Kent, Thomas A.
AU - Preskorn, Sheldon H.
AU - Glotzbach, Robin K.
AU - Irwin, George H.
N1 - Funding Information:
From the Department of Psychiatry and Pharmacology, University of Kansas Medical Center, Kansas City, KS, Supported m pan by a Clinical Pharmacology Fellowship from the Pharmaceutical Manufacturers Association Foundation (T.A.K.) and by NINDCS Grant NS-17252 and NfMH Research Scientrst Development Award MH-00272 (S.H.P.). Address reprint requests to Dr. Thomas A. Kent. Department of Neurology. University of Texas Medical Branch, Galveston. TX 77550. Received May 21. 1985: rewed September 17. 1985.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1986/5
Y1 - 1986/5
N2 - The cerebromicrocirculation in the tetrabenzaine (TBZ) model of depression has been found to be abnormal with respect to (1) responsiveness of cerebral blood flow to increases in arterial CO2 content and (2) the effective permeability of the blood-brain barrier to water. Development of these abnormalities temporally paralleled the behavioral disturbances and catecholamine depletion induced by TBZ. These TBZ-induced changes occurred globally throughout the brain, being apparent in the forebrain, cerebellum, and medulla-pons. Pretreatment with the antidepressant amitriptyline prevented both behavioral and physiological effects of TBZ, whereas amitriptyline administered after TBZ was less effective. The results suggest that an important action of tricyclic antidepressants may be cerebromicrocirculatory effects.
AB - The cerebromicrocirculation in the tetrabenzaine (TBZ) model of depression has been found to be abnormal with respect to (1) responsiveness of cerebral blood flow to increases in arterial CO2 content and (2) the effective permeability of the blood-brain barrier to water. Development of these abnormalities temporally paralleled the behavioral disturbances and catecholamine depletion induced by TBZ. These TBZ-induced changes occurred globally throughout the brain, being apparent in the forebrain, cerebellum, and medulla-pons. Pretreatment with the antidepressant amitriptyline prevented both behavioral and physiological effects of TBZ, whereas amitriptyline administered after TBZ was less effective. The results suggest that an important action of tricyclic antidepressants may be cerebromicrocirculatory effects.
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U2 - 10.1016/0006-3223(86)90190-3
DO - 10.1016/0006-3223(86)90190-3
M3 - Article
C2 - 3697438
AN - SCOPUS:0022508635
SN - 0006-3223
VL - 21
SP - 483
EP - 491
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 5-6
ER -