An anatomic transcriptional atlas of human glioblastoma

Ralph B. Puchalski; Nameeta Shah; Jeremy Miller; Rachel Dalley; Steve R. Nomura; Jae Guen Yoon; Kimberly A. Smith; Michael Lankerovich; Darren Bertagnolli; Kris Bickley; Andrew F. Boe; Krissy Brouner; Stephanie Butler; Shiella Caldejon; Mike Chapin; Suvro Datta; Nick Dee; Tsega Desta; Tim Dolbeare; Nadezhda Dotson; Amanda Ebbert; David Feng; Xu Feng; Michael Fisher; Garrett Gee; Jeff Goldy; Lindsey Gourley; Benjamin W. Gregor; Guangyu Gu; Nika Hejazinia; John Hohmann; Parvinder Hothi; Robert Howard; Kevin Joines; Ali Kriedberg; Leonard Kuan; Chris Lau; Felix Lee; Hwahyung Lee; Tracy Lemon; Fuhui Long; Naveed Mastan; Erika Mott; Chantal Murthy; Kiet Ngo; Eric Olson; Melissa Reding; Zack Riley; David Rosen; David Sandman; Nadiya Shapovalova; Clifford R. Slaughterbeck; Andrew Sodt; Graham Stockdale; Aaron Szafer; Wayne Wakeman; Paul E. Wohnoutka; Steven J. White; Don Marsh; Robert C. Rostomily; Lydia Ng; Chinh Dang; Allan Jones; Bart Keogh; Haley R. Gittleman; Jill S. Barnholtz-Sloan; Patrick J. Cimino; Megha S. Uppin; C. Dirk Keene; Farrokh R. Farrokhi; Justin D. Lathia; Michael E. Berens; Antonio Iavarone; Amy Bernard; Ed Lein; John W. Phillips; Steven W. Rostad; Charles Cobbs; Michael J. Hawrylycz; Greg D. Foltz

doi:10.1126/science.aaf2666

An anatomic transcriptional atlas of human glioblastoma

Ralph B. Puchalski, Nameeta Shah, Jeremy Miller, Rachel Dalley, Steve R. Nomura, Jae Guen Yoon, Kimberly A. Smith, Michael Lankerovich, Darren Bertagnolli, Kris Bickley, Andrew F. Boe, Krissy Brouner, Stephanie Butler, Shiella Caldejon, Mike Chapin, Suvro Datta, Nick Dee, Tsega Desta, Tim Dolbeare, Nadezhda DotsonAmanda Ebbert, David Feng, Xu Feng, Michael Fisher, Garrett Gee, Jeff Goldy, Lindsey Gourley, Benjamin W. Gregor, Guangyu Gu, Nika Hejazinia, John Hohmann, Parvinder Hothi, Robert Howard, Kevin Joines, Ali Kriedberg, Leonard Kuan, Chris Lau, Felix Lee, Hwahyung Lee, Tracy Lemon, Fuhui Long, Naveed Mastan, Erika Mott, Chantal Murthy, Kiet Ngo, Eric Olson, Melissa Reding, Zack Riley, David Rosen, David Sandman, Nadiya Shapovalova, Clifford R. Slaughterbeck, Andrew Sodt, Graham Stockdale, Aaron Szafer, Wayne Wakeman, Paul E. Wohnoutka, Steven J. White, Don Marsh, Robert C. Rostomily, Lydia Ng, Chinh Dang, Allan Jones, Bart Keogh, Haley R. Gittleman, Jill S. Barnholtz-Sloan, Patrick J. Cimino, Megha S. Uppin, C. Dirk Keene, Farrokh R. Farrokhi, Justin D. Lathia, Michael E. Berens, Antonio Iavarone, Amy Bernard, Ed Lein, John W. Phillips, Steven W. Rostad, Charles Cobbs, Michael J. Hawrylycz, Greg D. Foltz

Research output: Contribution to journal › Article › peer-review

324 Scopus citations

Abstract

Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor’s molecular and cellular landscapes are complex, and their relationships to histologic features routinely used for diagnosis are unclear. We present the Ivy Glioblastoma Atlas, an anatomically based transcriptional atlas of human glioblastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor. The atlas and its clinical and genomic database are freely accessible online data resources that will serve as a valuable platform for future investigations of glioblastoma pathogenesis, diagnosis, and treatment.

Original language	English (US)
Pages (from-to)	660-663
Number of pages	4
Journal	Science
Volume	360
Issue number	6389
DOIs	https://doi.org/10.1126/science.aaf2666
State	Published - May 11 2018

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Puchalski, R. B., Shah, N., Miller, J., Dalley, R., Nomura, S. R., Yoon, J. G., Smith, K. A., Lankerovich, M., Bertagnolli, D., Bickley, K., Boe, A. F., Brouner, K., Butler, S., Caldejon, S., Chapin, M., Datta, S., Dee, N., Desta, T., Dolbeare, T., ... Foltz, G. D. (2018). An anatomic transcriptional atlas of human glioblastoma. Science, 360(6389), 660-663. https://doi.org/10.1126/science.aaf2666

Puchalski, RB, Shah, N, Miller, J, Dalley, R, Nomura, SR, Yoon, JG, Smith, KA, Lankerovich, M, Bertagnolli, D, Bickley, K, Boe, AF, Brouner, K, Butler, S, Caldejon, S, Chapin, M, Datta, S, Dee, N, Desta, T, Dolbeare, T, Dotson, N, Ebbert, A, Feng, D, Feng, X, Fisher, M, Gee, G, Goldy, J, Gourley, L, Gregor, BW, Gu, G, Hejazinia, N, Hohmann, J, Hothi, P, Howard, R, Joines, K, Kriedberg, A, Kuan, L, Lau, C, Lee, F, Lee, H, Lemon, T, Long, F, Mastan, N, Mott, E, Murthy, C, Ngo, K, Olson, E, Reding, M, Riley, Z, Rosen, D, Sandman, D, Shapovalova, N, Slaughterbeck, CR, Sodt, A, Stockdale, G, Szafer, A, Wakeman, W, Wohnoutka, PE, White, SJ, Marsh, D, Rostomily, RC, Ng, L, Dang, C, Jones, A, Keogh, B, Gittleman, HR, Barnholtz-Sloan, JS, Cimino, PJ, Uppin, MS, Dirk Keene, C, Farrokhi, FR, Lathia, JD, Berens, ME, Iavarone, A, Bernard, A, Lein, E, Phillips, JW, Rostad, SW, Cobbs, C, Hawrylycz, MJ & Foltz, GD 2018, 'An anatomic transcriptional atlas of human glioblastoma', Science, vol. 360, no. 6389, pp. 660-663. https://doi.org/10.1126/science.aaf2666

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title = "An anatomic transcriptional atlas of human glioblastoma",

abstract = "Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor{\textquoteright}s molecular and cellular landscapes are complex, and their relationships to histologic features routinely used for diagnosis are unclear. We present the Ivy Glioblastoma Atlas, an anatomically based transcriptional atlas of human glioblastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor. The atlas and its clinical and genomic database are freely accessible online data resources that will serve as a valuable platform for future investigations of glioblastoma pathogenesis, diagnosis, and treatment.",

author = "Puchalski, {Ralph B.} and Nameeta Shah and Jeremy Miller and Rachel Dalley and Nomura, {Steve R.} and Yoon, {Jae Guen} and Smith, {Kimberly A.} and Michael Lankerovich and Darren Bertagnolli and Kris Bickley and Boe, {Andrew F.} and Krissy Brouner and Stephanie Butler and Shiella Caldejon and Mike Chapin and Suvro Datta and Nick Dee and Tsega Desta and Tim Dolbeare and Nadezhda Dotson and Amanda Ebbert and David Feng and Xu Feng and Michael Fisher and Garrett Gee and Jeff Goldy and Lindsey Gourley and Gregor, {Benjamin W.} and Guangyu Gu and Nika Hejazinia and John Hohmann and Parvinder Hothi and Robert Howard and Kevin Joines and Ali Kriedberg and Leonard Kuan and Chris Lau and Felix Lee and Hwahyung Lee and Tracy Lemon and Fuhui Long and Naveed Mastan and Erika Mott and Chantal Murthy and Kiet Ngo and Eric Olson and Melissa Reding and Zack Riley and David Rosen and David Sandman and Nadiya Shapovalova and Slaughterbeck, {Clifford R.} and Andrew Sodt and Graham Stockdale and Aaron Szafer and Wayne Wakeman and Wohnoutka, {Paul E.} and White, {Steven J.} and Don Marsh and Rostomily, {Robert C.} and Lydia Ng and Chinh Dang and Allan Jones and Bart Keogh and Gittleman, {Haley R.} and Barnholtz-Sloan, {Jill S.} and Cimino, {Patrick J.} and Uppin, {Megha S.} and {Dirk Keene}, C. and Farrokhi, {Farrokh R.} and Lathia, {Justin D.} and Berens, {Michael E.} and Antonio Iavarone and Amy Bernard and Ed Lein and Phillips, {John W.} and Rostad, {Steven W.} and Charles Cobbs and Hawrylycz, {Michael J.} and Foltz, {Greg D.}",

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year = "2018",

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doi = "10.1126/science.aaf2666",

language = "English (US)",

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AU - Shah, Nameeta

AU - Miller, Jeremy

AU - Dalley, Rachel

AU - Nomura, Steve R.

AU - Yoon, Jae Guen

AU - Smith, Kimberly A.

AU - Lankerovich, Michael

AU - Bertagnolli, Darren

AU - Bickley, Kris

AU - Boe, Andrew F.

AU - Brouner, Krissy

AU - Butler, Stephanie

AU - Caldejon, Shiella

AU - Chapin, Mike

AU - Datta, Suvro

AU - Dee, Nick

AU - Desta, Tsega

AU - Dolbeare, Tim

AU - Dotson, Nadezhda

AU - Ebbert, Amanda

AU - Feng, David

AU - Feng, Xu

AU - Fisher, Michael

AU - Gee, Garrett

AU - Goldy, Jeff

AU - Gourley, Lindsey

AU - Gregor, Benjamin W.

AU - Gu, Guangyu

AU - Hejazinia, Nika

AU - Hohmann, John

AU - Hothi, Parvinder

AU - Howard, Robert

AU - Joines, Kevin

AU - Kriedberg, Ali

AU - Kuan, Leonard

AU - Lau, Chris

AU - Lee, Felix

AU - Lee, Hwahyung

AU - Lemon, Tracy

AU - Long, Fuhui

AU - Mastan, Naveed

AU - Mott, Erika

AU - Murthy, Chantal

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AU - Olson, Eric

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AU - Ng, Lydia

AU - Dang, Chinh

AU - Jones, Allan

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AU - Cimino, Patrick J.

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AU - Dirk Keene, C.

AU - Farrokhi, Farrokh R.

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AU - Berens, Michael E.

AU - Iavarone, Antonio

AU - Bernard, Amy

AU - Lein, Ed

AU - Phillips, John W.

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AU - Cobbs, Charles

AU - Hawrylycz, Michael J.

AU - Foltz, Greg D.

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Y1 - 2018/5/11

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AB - Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor’s molecular and cellular landscapes are complex, and their relationships to histologic features routinely used for diagnosis are unclear. We present the Ivy Glioblastoma Atlas, an anatomically based transcriptional atlas of human glioblastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor. The atlas and its clinical and genomic database are freely accessible online data resources that will serve as a valuable platform for future investigations of glioblastoma pathogenesis, diagnosis, and treatment.

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An anatomic transcriptional atlas of human glioblastoma

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