TY - GEN
T1 - An integrative bioinformatics approach for identifying subtypes and subtype-specific drivers in cancer
AU - Chen, Peikai
AU - Hung, Y. S.
AU - Fan, Yubo
AU - Wong, Stephen T C
PY - 2012
Y1 - 2012
N2 - Cancer is a complex disease and within a cancer, subtypes of patients with distinct behaviors often exist. The subtypes might have been caused by different hits, such as copy number aberrations (CNAs) and point mutations, on different pathways/cells-of-origin in a common tissue/organ. Identifying the subtypes with subtype-specific drivers, i.e., hits, is key to the understanding of cancer and development of novel treatments.
AB - Cancer is a complex disease and within a cancer, subtypes of patients with distinct behaviors often exist. The subtypes might have been caused by different hits, such as copy number aberrations (CNAs) and point mutations, on different pathways/cells-of-origin in a common tissue/organ. Identifying the subtypes with subtype-specific drivers, i.e., hits, is key to the understanding of cancer and development of novel treatments.
UR - http://www.scopus.com/inward/record.url?scp=84864033158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864033158&partnerID=8YFLogxK
U2 - 10.1109/CIBCB.2012.6217227
DO - 10.1109/CIBCB.2012.6217227
M3 - Conference contribution
AN - SCOPUS:84864033158
SN - 9781467311892
T3 - 2012 IEEE Symposium on Computational Intelligence and Computational Biology, CIBCB 2012
SP - 169
EP - 176
BT - 2012 IEEE Symposium on Computational Intelligence and Computational Biology, CIBCB 2012
T2 - 2012 IEEE Symposium on Computational Intelligence and Computational Biology, CIBCB 2012
Y2 - 9 May 2012 through 12 May 2012
ER -