TY - JOUR
T1 - An overview of the use of nanozymes in antibacterial applications
AU - Mei, Linqiang
AU - Zhu, Shuang
AU - Liu, Yaping
AU - Yin, Wenyan
AU - Gu, Zhanjun
AU - Zhao, Yuliang
N1 - Funding Information:
This work was supported by the Strategic Priority Research Program of Chinese Academy of Sciences (XDB36000000), the National Basic Research Program of China (2020YFA0710702 and 2016YFA2021600), the National Natural Science Foundation of China (51822207, 51772292, U1932112, and 51772293), Chinese Academy of Sciences Youth Innovation Promotion Association (2013007), and Beijing Natural Science Foundation (2202064).
Publisher Copyright:
© 2021
PY - 2021/8/15
Y1 - 2021/8/15
N2 - Topics of bacterial resistance have attracted remarkable scientific interests. Bacterial infection-related diseases are major public safety issues that lead to millions of deaths annually. Therefore, it is urgent to develop novel, high efficiency, and bacteria-binding antibacterial agents. As far as now, the emergence of nanozymes has been presented as promising candidates to combat bacteria. Combining the advantages of nanomaterials and natural enzymes, such nanozymes are generally low cost, good stability, controllable size, easy-of-preparation, multifunctionality, and superior catalytic activity. As the potent antibacterial agents, nanozymes possess satisfying broad-spectrum antibacterial abilities and biocompatibility. Herein, we timely summarize the recent research progress of different kinds of nanozyme-based antibacterial agents. Additionally, the relevant antibacterial mechanisms of nanozymes and the roles of physicochemical properties, external stimuli, and surface modifications on their catalytic performances and biosafety are also discussed. Finally, current challenges and the future perspectives are covered to stimulate new strategies and more effective nanozyme-based antibacterial agents for preclinical translations.
AB - Topics of bacterial resistance have attracted remarkable scientific interests. Bacterial infection-related diseases are major public safety issues that lead to millions of deaths annually. Therefore, it is urgent to develop novel, high efficiency, and bacteria-binding antibacterial agents. As far as now, the emergence of nanozymes has been presented as promising candidates to combat bacteria. Combining the advantages of nanomaterials and natural enzymes, such nanozymes are generally low cost, good stability, controllable size, easy-of-preparation, multifunctionality, and superior catalytic activity. As the potent antibacterial agents, nanozymes possess satisfying broad-spectrum antibacterial abilities and biocompatibility. Herein, we timely summarize the recent research progress of different kinds of nanozyme-based antibacterial agents. Additionally, the relevant antibacterial mechanisms of nanozymes and the roles of physicochemical properties, external stimuli, and surface modifications on their catalytic performances and biosafety are also discussed. Finally, current challenges and the future perspectives are covered to stimulate new strategies and more effective nanozyme-based antibacterial agents for preclinical translations.
KW - Antibacterial
KW - Biosafety
KW - Catalytic performances
KW - Mechanisms
KW - Nanozymes
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U2 - 10.1016/j.cej.2021.129431
DO - 10.1016/j.cej.2021.129431
M3 - Review article
AN - SCOPUS:85103265491
SN - 1385-8947
VL - 418
JO - Chemical Engineering Journal
JF - Chemical Engineering Journal
M1 - 129431
ER -