TY - JOUR
T1 - An update on regulatory T cells in transplant tolerance and rejection
AU - Li, Xian Chang
AU - Turka, Laurence A.
PY - 2010/10
Y1 - 2010/10
N2 - Several types of T cells with immunosuppressive properties have been identified, but FOXP3 + regulatory T (TREG) cells have emerged as a dominant cell type; they are critically involved in the induction and maintenance of immune tolerance. Manipulation of this cell type for the induction of transplant tolerance including renal transplant tolerance has attracted considerable attention. Studies in this area have demonstrated unexpected complexities, and attempts to translate TREG cells towards clinical utility have met with unanticipated difficulties. In this Review, a broad overview is provided on recent progress in the study of TREG cells, focusing on challenges, opportunities, and emerging approaches in exploiting TREG cells for the induction of transplant tolerance.
AB - Several types of T cells with immunosuppressive properties have been identified, but FOXP3 + regulatory T (TREG) cells have emerged as a dominant cell type; they are critically involved in the induction and maintenance of immune tolerance. Manipulation of this cell type for the induction of transplant tolerance including renal transplant tolerance has attracted considerable attention. Studies in this area have demonstrated unexpected complexities, and attempts to translate TREG cells towards clinical utility have met with unanticipated difficulties. In this Review, a broad overview is provided on recent progress in the study of TREG cells, focusing on challenges, opportunities, and emerging approaches in exploiting TREG cells for the induction of transplant tolerance.
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U2 - 10.1038/nrneph.2010.101
DO - 10.1038/nrneph.2010.101
M3 - Review article
C2 - 20683480
AN - SCOPUS:77957558616
SN - 1759-5061
VL - 6
SP - 577
EP - 583
JO - Nature Reviews Nephrology
JF - Nature Reviews Nephrology
IS - 10
ER -