Abstract
Antibodies to small bioactive ligands and peptides may mimic the binding characteristics of the natural receptor; in turn, the anti-idiotypic antibodies generated against the binding sites of such anti-ligand antibodies may mimic some aspects of small bioactive ligands and peptides. Among the several levels of investigation of such antibody-receptor networks are (a) the quantitative structure-activity relationships of ligand binding to antibody as compared with natural receptor; (b) the molecular modeling of antibody-receptor binding sites and the genomic basis for such structures; and (c) the characteristics of the molecular mimicry exhibited by 'mimetopes' on anti-idiotypic antibodies. To illustrate the analysis encountered at each of these levels, we discuss here antibody and anti-idiotype systems that are directed to small neuroactive ligands and their receptors.
Original language | English (US) |
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Pages (from-to) | 1676-1680 |
Number of pages | 5 |
Journal | Clinical Chemistry |
Volume | 34 |
Issue number | 9 |
DOIs | |
State | Published - 1988 |
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical