Aneurysm growth and thrombus formation in the basilar artery

Liang Der Jou; David Saloner; Brad Dispensa; William L. Young

doi:10.1115/imece2004-62424

Aneurysm growth and thrombus formation in the basilar artery

Liang Der Jou, David Saloner, Brad Dispensa, William L. Young

Academic Institute

Research output: Contribution to journal › Conference article › peer-review

Abstract

Modifying aneurysm hemodynamics may reduce the likelihood of aneurysm rupture. In this study, hemodynamics in a growing aneurysm and a thrombus-developing basilar aneurysm is studied. The locations of thrombus and growth were identified by co-registering MR images of aneurysms at two different times. The thrombus (∼6mm) appeared at the superior side of the aneurysm, where the flow impinged on the wall, and aneurysm growth (∼3mm) was found at the inferior side (lower part) of the aneurysm. The wall shear stress was calculated from flow simulations. The location of growth has a very low wall shear stress (< 0.01N/m²). The change of hemodynamics during thrombus development was not significant, but the thickest thrombus was shown to have a wall shear stress level between 0.2 and 1N/m².

Original language	English (US)
Article number	IMECE2004-62424
Pages (from-to)	65-66
Number of pages	2
Journal	Advances in Bioengineering, BED
DOIs	https://doi.org/10.1115/imece2004-62424
State	Published - 2004
Event	2004 ASME International Mechanical Engineering Congress and Exposition, IMECE - Anaheim, CA, United States Duration: Nov 13 2004 → Nov 19 2004

Keywords

Cerebral aneurysms
Hemodynamics
Thrombus

ASJC Scopus subject areas

Engineering(all)

Access to Document

10.1115/imece2004-62424

Cite this

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title = "Aneurysm growth and thrombus formation in the basilar artery",

abstract = "Modifying aneurysm hemodynamics may reduce the likelihood of aneurysm rupture. In this study, hemodynamics in a growing aneurysm and a thrombus-developing basilar aneurysm is studied. The locations of thrombus and growth were identified by co-registering MR images of aneurysms at two different times. The thrombus (∼6mm) appeared at the superior side of the aneurysm, where the flow impinged on the wall, and aneurysm growth (∼3mm) was found at the inferior side (lower part) of the aneurysm. The wall shear stress was calculated from flow simulations. The location of growth has a very low wall shear stress (< 0.01N/m2). The change of hemodynamics during thrombus development was not significant, but the thickest thrombus was shown to have a wall shear stress level between 0.2 and 1N/m2.",

keywords = "Cerebral aneurysms, Hemodynamics, Thrombus",

author = "Jou, {Liang Der} and David Saloner and Brad Dispensa and Young, {William L.}",

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doi = "10.1115/imece2004-62424",

language = "English (US)",

pages = "65--66",

journal = "Advances in Bioengineering, BED",

issn = "0360-9960",

note = "2004 ASME International Mechanical Engineering Congress and Exposition, IMECE ; Conference date: 13-11-2004 Through 19-11-2004",

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TY - JOUR

T1 - Aneurysm growth and thrombus formation in the basilar artery

AU - Jou, Liang Der

AU - Saloner, David

AU - Dispensa, Brad

AU - Young, William L.

PY - 2004

Y1 - 2004

N2 - Modifying aneurysm hemodynamics may reduce the likelihood of aneurysm rupture. In this study, hemodynamics in a growing aneurysm and a thrombus-developing basilar aneurysm is studied. The locations of thrombus and growth were identified by co-registering MR images of aneurysms at two different times. The thrombus (∼6mm) appeared at the superior side of the aneurysm, where the flow impinged on the wall, and aneurysm growth (∼3mm) was found at the inferior side (lower part) of the aneurysm. The wall shear stress was calculated from flow simulations. The location of growth has a very low wall shear stress (< 0.01N/m2). The change of hemodynamics during thrombus development was not significant, but the thickest thrombus was shown to have a wall shear stress level between 0.2 and 1N/m2.

AB - Modifying aneurysm hemodynamics may reduce the likelihood of aneurysm rupture. In this study, hemodynamics in a growing aneurysm and a thrombus-developing basilar aneurysm is studied. The locations of thrombus and growth were identified by co-registering MR images of aneurysms at two different times. The thrombus (∼6mm) appeared at the superior side of the aneurysm, where the flow impinged on the wall, and aneurysm growth (∼3mm) was found at the inferior side (lower part) of the aneurysm. The wall shear stress was calculated from flow simulations. The location of growth has a very low wall shear stress (< 0.01N/m2). The change of hemodynamics during thrombus development was not significant, but the thickest thrombus was shown to have a wall shear stress level between 0.2 and 1N/m2.

KW - Cerebral aneurysms

KW - Hemodynamics

KW - Thrombus

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JO - Advances in Bioengineering, BED

JF - Advances in Bioengineering, BED

M1 - IMECE2004-62424

T2 - 2004 ASME International Mechanical Engineering Congress and Exposition, IMECE

Y2 - 13 November 2004 through 19 November 2004

ER -

Aneurysm growth and thrombus formation in the basilar artery

Abstract

Keywords

ASJC Scopus subject areas

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