Anterior Segment Optical Coherence Tomography of Ocular Cystinosis Confirmed by Electron Microscopy

Abhinav Golla; Mitchell P. Weikert; Patricia Chevez-Barrios; Zaina Al-Mohtaseb

doi:10.1159/000490389

Anterior Segment Optical Coherence Tomography of Ocular Cystinosis Confirmed by Electron Microscopy

Abhinav Golla, Mitchell P. Weikert, Patricia Chevez-Barrios, Zaina Al-Mohtaseb

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Abstract

Purpose: To report a case of ocular cystinosis diagnosed by anterior segment optical coherence tomography (AS-OCT) and histopathology. Methods: A 67-year-old man who presented with eye pain was found to have unilateral corneal crystal deposition. Ocular cystinosis was diagnosed by histopathology, AS-OCT, and lack of renal involvement of the disease. Results: AS-OCT showed hyperreflective densities in the corneal epithelium. The patient underwent superficial keratectomy given irregular astigmatism prior to cataract surgery. Electron microscopy of the corneal scrapings revealed epithelial cells with intracystoplasmic membrane-bound crystals confirming the diagnosis of cystinosis. Conclusion: To our knowledge, this is the first reported case of ocular cystinosis involving strictly the epithelial layer of the cornea that has been imaged by AS-OCT.

Original language	English (US)
Pages (from-to)	110-113
Number of pages	4
Journal	Ocular Oncology and Pathology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1159/000490389
State	Published - Feb 1 2019

Keywords

Anterior segment optical coherence tomography
Electron microscopy
Ocular cystinosis

ASJC Scopus subject areas

Nursing(all)

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10.1159/000490389

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title = "Anterior Segment Optical Coherence Tomography of Ocular Cystinosis Confirmed by Electron Microscopy",

abstract = "Purpose: To report a case of ocular cystinosis diagnosed by anterior segment optical coherence tomography (AS-OCT) and histopathology. Methods: A 67-year-old man who presented with eye pain was found to have unilateral corneal crystal deposition. Ocular cystinosis was diagnosed by histopathology, AS-OCT, and lack of renal involvement of the disease. Results: AS-OCT showed hyperreflective densities in the corneal epithelium. The patient underwent superficial keratectomy given irregular astigmatism prior to cataract surgery. Electron microscopy of the corneal scrapings revealed epithelial cells with intracystoplasmic membrane-bound crystals confirming the diagnosis of cystinosis. Conclusion: To our knowledge, this is the first reported case of ocular cystinosis involving strictly the epithelial layer of the cornea that has been imaged by AS-OCT.",

keywords = "Anterior segment optical coherence tomography, Electron microscopy, Ocular cystinosis",

author = "Abhinav Golla and Weikert, {Mitchell P.} and Patricia Chevez-Barrios and Zaina Al-Mohtaseb",

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doi = "10.1159/000490389",

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T1 - Anterior Segment Optical Coherence Tomography of Ocular Cystinosis Confirmed by Electron Microscopy

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AU - Weikert, Mitchell P.

AU - Chevez-Barrios, Patricia

AU - Al-Mohtaseb, Zaina

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Purpose: To report a case of ocular cystinosis diagnosed by anterior segment optical coherence tomography (AS-OCT) and histopathology. Methods: A 67-year-old man who presented with eye pain was found to have unilateral corneal crystal deposition. Ocular cystinosis was diagnosed by histopathology, AS-OCT, and lack of renal involvement of the disease. Results: AS-OCT showed hyperreflective densities in the corneal epithelium. The patient underwent superficial keratectomy given irregular astigmatism prior to cataract surgery. Electron microscopy of the corneal scrapings revealed epithelial cells with intracystoplasmic membrane-bound crystals confirming the diagnosis of cystinosis. Conclusion: To our knowledge, this is the first reported case of ocular cystinosis involving strictly the epithelial layer of the cornea that has been imaged by AS-OCT.

AB - Purpose: To report a case of ocular cystinosis diagnosed by anterior segment optical coherence tomography (AS-OCT) and histopathology. Methods: A 67-year-old man who presented with eye pain was found to have unilateral corneal crystal deposition. Ocular cystinosis was diagnosed by histopathology, AS-OCT, and lack of renal involvement of the disease. Results: AS-OCT showed hyperreflective densities in the corneal epithelium. The patient underwent superficial keratectomy given irregular astigmatism prior to cataract surgery. Electron microscopy of the corneal scrapings revealed epithelial cells with intracystoplasmic membrane-bound crystals confirming the diagnosis of cystinosis. Conclusion: To our knowledge, this is the first reported case of ocular cystinosis involving strictly the epithelial layer of the cornea that has been imaged by AS-OCT.

KW - Anterior segment optical coherence tomography

KW - Electron microscopy

KW - Ocular cystinosis

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Anterior Segment Optical Coherence Tomography of Ocular Cystinosis Confirmed by Electron Microscopy

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