Antiviral effects of Stichopus japonicus acid mucopolysaccharide on hepatitis B virus transgenic mice

Yongning Xin; Wei Li; Linlin Lu; Li Zhou; David W. Victor; Shiying Xuan

doi:10.1007/s11802-016-3124-4

Antiviral effects of Stichopus japonicus acid mucopolysaccharide on hepatitis B virus transgenic mice

Yongning Xin, Wei Li, Linlin Lu, Li Zhou, David W. Victor, Shiying Xuan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Hepatitis B virus (HBV) is a significant global pathogen and efficient cure for HBV patients is still a challenging goal. We previously reported that acidic mucopolysaccharide from stichopus japonicus selenka (SJAMP) could inhibit HBsAg and HBeAg expression in vitro. However, the potential anti-HBV effects of SJAMP in vivo have not yet been explored. In this study, we show that SJAMP exhibits potent anti-HBV activity in HBV transgenic mice in a dose-dependent manner. Specifically, sixty HBV transgenic male BALB/c mice were randomly selected to receive the treatment of PBS, low dose SJAMP (30 mg kg⁻¹), middle dose SJAMP (40 mg kg⁻¹), high dose SJAMP (50 mg kg⁻¹) and IFN (45 IU kg⁻¹) for 30 d. SJAMP treatment suppressed serum HBV-DNA, and liver HBsAg and HBcAg levels in HBV-transgenic mice. The present study highlights the potential application of SJAMP in HBV therapy.

Original language	English (US)
Pages (from-to)	719-725
Number of pages	7
Journal	Journal of Ocean University of China
Volume	15
Issue number	4
DOIs	https://doi.org/10.1007/s11802-016-3124-4
State	Published - Aug 1 2016

Keywords

Stichopus japonicus acid mucopolysaccharide
antiviral
hepatitis B virus
transgenic mice

ASJC Scopus subject areas

Oceanography
Ocean Engineering

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10.1007/s11802-016-3124-4

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title = "Antiviral effects of Stichopus japonicus acid mucopolysaccharide on hepatitis B virus transgenic mice",

abstract = "Hepatitis B virus (HBV) is a significant global pathogen and efficient cure for HBV patients is still a challenging goal. We previously reported that acidic mucopolysaccharide from stichopus japonicus selenka (SJAMP) could inhibit HBsAg and HBeAg expression in vitro. However, the potential anti-HBV effects of SJAMP in vivo have not yet been explored. In this study, we show that SJAMP exhibits potent anti-HBV activity in HBV transgenic mice in a dose-dependent manner. Specifically, sixty HBV transgenic male BALB/c mice were randomly selected to receive the treatment of PBS, low dose SJAMP (30 mg kg−1), middle dose SJAMP (40 mg kg−1), high dose SJAMP (50 mg kg−1) and IFN (45 IU kg−1) for 30 d. SJAMP treatment suppressed serum HBV-DNA, and liver HBsAg and HBcAg levels in HBV-transgenic mice. The present study highlights the potential application of SJAMP in HBV therapy.",

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author = "Yongning Xin and Wei Li and Linlin Lu and Li Zhou and Victor, {David W.} and Shiying Xuan",

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doi = "10.1007/s11802-016-3124-4",

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T1 - Antiviral effects of Stichopus japonicus acid mucopolysaccharide on hepatitis B virus transgenic mice

AU - Xin, Yongning

AU - Li, Wei

AU - Lu, Linlin

AU - Zhou, Li

AU - Victor, David W.

AU - Xuan, Shiying

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Hepatitis B virus (HBV) is a significant global pathogen and efficient cure for HBV patients is still a challenging goal. We previously reported that acidic mucopolysaccharide from stichopus japonicus selenka (SJAMP) could inhibit HBsAg and HBeAg expression in vitro. However, the potential anti-HBV effects of SJAMP in vivo have not yet been explored. In this study, we show that SJAMP exhibits potent anti-HBV activity in HBV transgenic mice in a dose-dependent manner. Specifically, sixty HBV transgenic male BALB/c mice were randomly selected to receive the treatment of PBS, low dose SJAMP (30 mg kg−1), middle dose SJAMP (40 mg kg−1), high dose SJAMP (50 mg kg−1) and IFN (45 IU kg−1) for 30 d. SJAMP treatment suppressed serum HBV-DNA, and liver HBsAg and HBcAg levels in HBV-transgenic mice. The present study highlights the potential application of SJAMP in HBV therapy.

AB - Hepatitis B virus (HBV) is a significant global pathogen and efficient cure for HBV patients is still a challenging goal. We previously reported that acidic mucopolysaccharide from stichopus japonicus selenka (SJAMP) could inhibit HBsAg and HBeAg expression in vitro. However, the potential anti-HBV effects of SJAMP in vivo have not yet been explored. In this study, we show that SJAMP exhibits potent anti-HBV activity in HBV transgenic mice in a dose-dependent manner. Specifically, sixty HBV transgenic male BALB/c mice were randomly selected to receive the treatment of PBS, low dose SJAMP (30 mg kg−1), middle dose SJAMP (40 mg kg−1), high dose SJAMP (50 mg kg−1) and IFN (45 IU kg−1) for 30 d. SJAMP treatment suppressed serum HBV-DNA, and liver HBsAg and HBcAg levels in HBV-transgenic mice. The present study highlights the potential application of SJAMP in HBV therapy.

KW - Stichopus japonicus acid mucopolysaccharide

KW - antiviral

KW - hepatitis B virus

KW - transgenic mice

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Antiviral effects of Stichopus japonicus acid mucopolysaccharide on hepatitis B virus transgenic mice

Abstract

Keywords

ASJC Scopus subject areas

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