TY - GEN
T1 - Application of a viscous liquid as an aerosol for post-operative adhesion prevention
T2 - 2021 Design of Medical Devices Conference, DMD 2021
AU - Smith, P. Alex
AU - Keane, Timothy J.
AU - Serpelloni, Stefano
AU - Ramon, Stephen G.
AU - Taraballi, Francesca
N1 - Publisher Copyright:
© 2021 by ASME.
PY - 2021
Y1 - 2021
N2 - Postoperative adhesions are scar tissue that form between internal organs after surgery, leading to devastating life-long complications. Current adhesion barriers used clinically are solid sheets which can only be applied in open surgeries through large incisions. We have developed a material which can be applied as a liquid in minimally invasive surgeries which transitions into a solid thin film barrier upon contact with warm tissue. However, to be effective, it must be sprayed, and spraying a viscous liquid consistently is challenging. We proposed using a gas dispersant to facilitate aerosolization. In this study, we compared a commercially available nozzle without gas dispersant to a custom 3D printed nozzle with gas dispersant. For comparison, we measured both spray pattern and stiffness of the resulting gel. We found that when sprayed with gas dispersant, the spray pattern covered a larger area, and the resulting gel was stiffer than when sprayed without gas dispersant.
AB - Postoperative adhesions are scar tissue that form between internal organs after surgery, leading to devastating life-long complications. Current adhesion barriers used clinically are solid sheets which can only be applied in open surgeries through large incisions. We have developed a material which can be applied as a liquid in minimally invasive surgeries which transitions into a solid thin film barrier upon contact with warm tissue. However, to be effective, it must be sprayed, and spraying a viscous liquid consistently is challenging. We proposed using a gas dispersant to facilitate aerosolization. In this study, we compared a commercially available nozzle without gas dispersant to a custom 3D printed nozzle with gas dispersant. For comparison, we measured both spray pattern and stiffness of the resulting gel. We found that when sprayed with gas dispersant, the spray pattern covered a larger area, and the resulting gel was stiffer than when sprayed without gas dispersant.
KW - Adhesion barrier
KW - Minimally invasive surgery
KW - Nozzle
KW - Postoperative adhesions
KW - Viscous aerosolization
UR - http://www.scopus.com/inward/record.url?scp=85107210348&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85107210348&partnerID=8YFLogxK
U2 - 10.1115/DMD2021-1064
DO - 10.1115/DMD2021-1064
M3 - Conference contribution
AN - SCOPUS:85107210348
T3 - Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021
BT - Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021
PB - American Society of Mechanical Engineers
Y2 - 12 April 2021 through 15 April 2021
ER -