Arterial Wall Stiffness and Atherogenesis in Human Coronaries

Jacques Ohayon; Saami K. Yazdani; Mauro Malvè; Ahmed M. Gharib; Alberto Garcia; Gérard Finet; Roderic I. Pettigrew

doi:10.1016/B978-0-12-804009-6.00009-2

Arterial Wall Stiffness and Atherogenesis in Human Coronaries

Jacques Ohayon, Saami K. Yazdani, Mauro Malvè, Ahmed M. Gharib, Alberto Garcia, Gérard Finet, Roderic I. Pettigrew

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Scopus citations

Abstract

The present study hypothesized that local wall-strain stiffening phenomena might, in addition to low endothelial shear stress (ESS) and cyclic stretch, be a complementary factor in plaque location in coronary bifurcations. Patients with minimal coronary disease, having undergone both computer tomography and magnetic resonance imaging examinations, were enrolled for the study. Both computational fluid dynamics and structural analysis were performed. The effects of cardiac motion and blood pressure on spatial luminal arterial wall stretch (LW_stretch), and stiffness (LW_stiff) distributions in the left main coronary bifurcations, were investigated. No correlations were found between LW_Stiff, LW_Stretch, and ESS at lesion sites. However, results indicated that 89% of lesions were located at sites of low ESS (i.e., ESS<1Pa) and, more interestingly, also in specific regions of high LW_Stiff (LW_Stiff>300kPa). These findings underline the importance of arterial wall stiffness in the development of atherosclerosis.

Original language	English (US)
Title of host publication	Biomechanics of Living Organs
Subtitle of host publication	Hyperelastic Constitutive Laws for Finite Element Modeling
Publisher	Elsevier
Pages	193-213
Number of pages	21
ISBN (Electronic)	9780128040607
ISBN (Print)	9780128040096
DOIs	https://doi.org/10.1016/B978-0-12-804009-6.00009-2
State	Published - Jan 1 2017

Keywords

Atherosclerosis
Biomechanics
Coronary disease
Endothelial shear stress
Finite element analysis
Fluid mechanics
Solid mechanics
Wall stiffness
Wall stress

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-804009-6.00009-2

Cite this

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abstract = "The present study hypothesized that local wall-strain stiffening phenomena might, in addition to low endothelial shear stress (ESS) and cyclic stretch, be a complementary factor in plaque location in coronary bifurcations. Patients with minimal coronary disease, having undergone both computer tomography and magnetic resonance imaging examinations, were enrolled for the study. Both computational fluid dynamics and structural analysis were performed. The effects of cardiac motion and blood pressure on spatial luminal arterial wall stretch (LWstretch), and stiffness (LWstiff) distributions in the left main coronary bifurcations, were investigated. No correlations were found between LWStiff, LWStretch, and ESS at lesion sites. However, results indicated that 89% of lesions were located at sites of low ESS (i.e., ESS<1Pa) and, more interestingly, also in specific regions of high LWStiff (LWStiff>300kPa). These findings underline the importance of arterial wall stiffness in the development of atherosclerosis.",

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AU - Yazdani, Saami K.

AU - Malvè, Mauro

AU - Gharib, Ahmed M.

AU - Garcia, Alberto

AU - Finet, Gérard

AU - Pettigrew, Roderic I.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - The present study hypothesized that local wall-strain stiffening phenomena might, in addition to low endothelial shear stress (ESS) and cyclic stretch, be a complementary factor in plaque location in coronary bifurcations. Patients with minimal coronary disease, having undergone both computer tomography and magnetic resonance imaging examinations, were enrolled for the study. Both computational fluid dynamics and structural analysis were performed. The effects of cardiac motion and blood pressure on spatial luminal arterial wall stretch (LWstretch), and stiffness (LWstiff) distributions in the left main coronary bifurcations, were investigated. No correlations were found between LWStiff, LWStretch, and ESS at lesion sites. However, results indicated that 89% of lesions were located at sites of low ESS (i.e., ESS<1Pa) and, more interestingly, also in specific regions of high LWStiff (LWStiff>300kPa). These findings underline the importance of arterial wall stiffness in the development of atherosclerosis.

AB - The present study hypothesized that local wall-strain stiffening phenomena might, in addition to low endothelial shear stress (ESS) and cyclic stretch, be a complementary factor in plaque location in coronary bifurcations. Patients with minimal coronary disease, having undergone both computer tomography and magnetic resonance imaging examinations, were enrolled for the study. Both computational fluid dynamics and structural analysis were performed. The effects of cardiac motion and blood pressure on spatial luminal arterial wall stretch (LWstretch), and stiffness (LWstiff) distributions in the left main coronary bifurcations, were investigated. No correlations were found between LWStiff, LWStretch, and ESS at lesion sites. However, results indicated that 89% of lesions were located at sites of low ESS (i.e., ESS<1Pa) and, more interestingly, also in specific regions of high LWStiff (LWStiff>300kPa). These findings underline the importance of arterial wall stiffness in the development of atherosclerosis.

KW - Atherosclerosis

KW - Biomechanics

KW - Coronary disease

KW - Endothelial shear stress

KW - Finite element analysis

KW - Fluid mechanics

KW - Solid mechanics

KW - Wall stiffness

KW - Wall stress

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ER -

Arterial Wall Stiffness and Atherogenesis in Human Coronaries

Abstract

Keywords

ASJC Scopus subject areas

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