Aspiration biopsy of osseous metastasis of retroperitoneal paraganglioma: Report of a case with cytologic features and differential diagnostic considerations

K. J. Absher; D. A. Witte; Luan Truong; I. Ramzy; Dina R. Mody; M. L. Ostrowski

doi:10.1159/000327284

Aspiration biopsy of osseous metastasis of retroperitoneal paraganglioma: Report of a case with cytologic features and differential diagnostic considerations

K. J. Absher, D. A. Witte, Luan Truong, I. Ramzy, Dina R. Mody, M. L. Ostrowski

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

BACKGROUND: Paragangliomas are uncommon tumors, only 10% of which are malignant, as evidenced by metastatic disease. It is rare for paraganglioma to present with symptomatic osseous metastases. CASE: A retroperitoneal paraganglioma presented in a 52-year-old man as painful metastases in the rib and vertebrae. Fine needle aspiration (FNA) of a lumbar vertebral lesion showed cells arranged singly and in loose clusters with fragile, vacuolated or finely granular cytoplasm, marked anisonucleosis and mitoses. Rare zellballen-type structures and intranuclear inclusions were present. Immunohistochemical studies of a subsequent FNA core biopsy of the retroperitoneal mass showed strong immunoreactivity with chromogranin and negative staining for keratin; that was helpful in differentiating this tumor from others in the differential diagnosis. CONCLUSION: The cytologic diagnosis of paraganglioma is difficult as these tumors exhibit a plethora of features that overlap those of many other neoplasms. The diagnosis can be confirmed with appropriate immunohistochemical studies of corresponding core biopsies.

Original language	English (US)
Pages (from-to)	249-253
Number of pages	5
Journal	Acta Cytologica
Volume	45
Issue number	2
DOIs	https://doi.org/10.1159/000327284
State	Published - Jan 1 2001

Keywords

Aspiration biopsy
Bone neoplasms
Metastasis
Paraganglioma
Retroperitoneal neoplasms

ASJC Scopus subject areas

Anatomy
Cell Biology
Histology

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title = "Aspiration biopsy of osseous metastasis of retroperitoneal paraganglioma: Report of a case with cytologic features and differential diagnostic considerations",

abstract = "BACKGROUND: Paragangliomas are uncommon tumors, only 10% of which are malignant, as evidenced by metastatic disease. It is rare for paraganglioma to present with symptomatic osseous metastases. CASE: A retroperitoneal paraganglioma presented in a 52-year-old man as painful metastases in the rib and vertebrae. Fine needle aspiration (FNA) of a lumbar vertebral lesion showed cells arranged singly and in loose clusters with fragile, vacuolated or finely granular cytoplasm, marked anisonucleosis and mitoses. Rare zellballen-type structures and intranuclear inclusions were present. Immunohistochemical studies of a subsequent FNA core biopsy of the retroperitoneal mass showed strong immunoreactivity with chromogranin and negative staining for keratin; that was helpful in differentiating this tumor from others in the differential diagnosis. CONCLUSION: The cytologic diagnosis of paraganglioma is difficult as these tumors exhibit a plethora of features that overlap those of many other neoplasms. The diagnosis can be confirmed with appropriate immunohistochemical studies of corresponding core biopsies.",

keywords = "Aspiration biopsy, Bone neoplasms, Metastasis, Paraganglioma, Retroperitoneal neoplasms",

author = "Absher, {K. J.} and Witte, {D. A.} and Luan Truong and I. Ramzy and Mody, {Dina R.} and Ostrowski, {M. L.}",

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AU - Absher, K. J.

AU - Witte, D. A.

AU - Truong, Luan

AU - Ramzy, I.

AU - Mody, Dina R.

AU - Ostrowski, M. L.

PY - 2001/1/1

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N2 - BACKGROUND: Paragangliomas are uncommon tumors, only 10% of which are malignant, as evidenced by metastatic disease. It is rare for paraganglioma to present with symptomatic osseous metastases. CASE: A retroperitoneal paraganglioma presented in a 52-year-old man as painful metastases in the rib and vertebrae. Fine needle aspiration (FNA) of a lumbar vertebral lesion showed cells arranged singly and in loose clusters with fragile, vacuolated or finely granular cytoplasm, marked anisonucleosis and mitoses. Rare zellballen-type structures and intranuclear inclusions were present. Immunohistochemical studies of a subsequent FNA core biopsy of the retroperitoneal mass showed strong immunoreactivity with chromogranin and negative staining for keratin; that was helpful in differentiating this tumor from others in the differential diagnosis. CONCLUSION: The cytologic diagnosis of paraganglioma is difficult as these tumors exhibit a plethora of features that overlap those of many other neoplasms. The diagnosis can be confirmed with appropriate immunohistochemical studies of corresponding core biopsies.

AB - BACKGROUND: Paragangliomas are uncommon tumors, only 10% of which are malignant, as evidenced by metastatic disease. It is rare for paraganglioma to present with symptomatic osseous metastases. CASE: A retroperitoneal paraganglioma presented in a 52-year-old man as painful metastases in the rib and vertebrae. Fine needle aspiration (FNA) of a lumbar vertebral lesion showed cells arranged singly and in loose clusters with fragile, vacuolated or finely granular cytoplasm, marked anisonucleosis and mitoses. Rare zellballen-type structures and intranuclear inclusions were present. Immunohistochemical studies of a subsequent FNA core biopsy of the retroperitoneal mass showed strong immunoreactivity with chromogranin and negative staining for keratin; that was helpful in differentiating this tumor from others in the differential diagnosis. CONCLUSION: The cytologic diagnosis of paraganglioma is difficult as these tumors exhibit a plethora of features that overlap those of many other neoplasms. The diagnosis can be confirmed with appropriate immunohistochemical studies of corresponding core biopsies.

KW - Aspiration biopsy

KW - Bone neoplasms

KW - Metastasis

KW - Paraganglioma

KW - Retroperitoneal neoplasms

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Aspiration biopsy of osseous metastasis of retroperitoneal paraganglioma: Report of a case with cytologic features and differential diagnostic considerations

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