Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group

Fay Betsou; Alexandre Bulla; Sang Yun Cho; Judith Clements; Rodrigo Chuaqui; Domenico Coppola; Yvonne De Souza; Annemieke De Wilde; William Grizzle; Fiorella Guadagni; Elaine Gunter; Stacey Heil; Verity Hodgkinson; Joseph Kessler; Michael Kiehntopf; Hee Sung Kim; Iren Koppandi; Katheryn Shea; Rajeev Singh; Marc Sobel; Stella Somiari; Demetri Spyropoulos; Mars Stone; Gunnel Tybring; Klara Valyi-Nagy; Gert Van Den Eynden; Lalita Wadhwa

doi:10.1089/bio.2016.0018

Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group

Fay Betsou, Alexandre Bulla, Sang Yun Cho, Judith Clements, Rodrigo Chuaqui, Domenico Coppola, Yvonne De Souza, Annemieke De Wilde, William Grizzle, Fiorella Guadagni, Elaine Gunter, Stacey Heil, Verity Hodgkinson, Joseph Kessler, Michael Kiehntopf, Hee Sung Kim, Iren Koppandi, Katheryn Shea, Rajeev Singh, Marc SobelStella Somiari, Demetri Spyropoulos, Mars Stone, Gunnel Tybring, Klara Valyi-Nagy, Gert Van Den Eynden, Lalita Wadhwa

Houston Methodist

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

This technical report presents quality control (QC) assays that can be performed in order to qualify clinical biospecimens that have been biobanked for use in research. Some QC assays are specific to a disease area. Some QC assays are specific to a particular downstream analytical platform. When such a qualification is not possible, QC assays are presented that can be performed to stratify clinical biospecimens according to their biomolecular quality.

Original language	English (US)
Pages (from-to)	398-409
Number of pages	12
Journal	Biopreservation and Biobanking
Volume	14
Issue number	5
DOIs	https://doi.org/10.1089/bio.2016.0018
State	Published - Oct 1 2016

Keywords

biological fluid
biospecimen
cells
qualification
quality control
tissue

ASJC Scopus subject areas

Medicine (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)
Cell Biology

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10.1089/bio.2016.0018

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Betsou, F., Bulla, A., Cho, S. Y., Clements, J., Chuaqui, R., Coppola, D., De Souza, Y., De Wilde, A., Grizzle, W., Guadagni, F., Gunter, E., Heil, S., Hodgkinson, V., Kessler, J., Kiehntopf, M., Kim, H. S., Koppandi, I., Shea, K., Singh, R., ... Wadhwa, L. (2016). Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group. Biopreservation and Biobanking, 14(5), 398-409. https://doi.org/10.1089/bio.2016.0018

Betsou, F, Bulla, A, Cho, SY, Clements, J, Chuaqui, R, Coppola, D, De Souza, Y, De Wilde, A, Grizzle, W, Guadagni, F, Gunter, E, Heil, S, Hodgkinson, V, Kessler, J, Kiehntopf, M, Kim, HS, Koppandi, I, Shea, K, Singh, R, Sobel, M, Somiari, S, Spyropoulos, D, Stone, M, Tybring, G, Valyi-Nagy, K, Van Den Eynden, G & Wadhwa, L 2016, 'Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group', Biopreservation and Biobanking, vol. 14, no. 5, pp. 398-409. https://doi.org/10.1089/bio.2016.0018

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Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group

Abstract

Keywords

ASJC Scopus subject areas

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