@article{77e65d2be8824668a2f9c1f2380f82f2,
title = "Association Between Change in Accelerometer-Measured and Self-Reported Physical Activity and Cardiovascular Disease in the Look AHEAD Trial",
abstract = "OBJECTIVE: To conduct post hoc secondary analysis examining the association between change in physical activity. Measured with self-report and accelerometry, from baseline to 1 and 4 years and cardiovascular disease (CVD) outcomes in the Look AHEAD Trial.RESEARCH DESIGN AND METHODS: Participants were adults with overweight/obesity and type 2 diabetes with physical activity. Data at baseline and year 1 or 4 (n = 1,978). Participants were randomized to diabetes support and education or intensive lifestyle intervention. Measures included accelerometry-measured moderate-to-vigorous physical activity (MVPA), self-reported physical activity, and composite (morbidity and mortality) CVD outcomes.RESULTS: In pooled analyses of all participants, using Cox proportional hazards models, each 100 MET-min/week increase in accelerometry-measured MVPA from baseline to 4 years was associated with decreased risk of the subsequent primary composite outcome of CVD. Results were consistent for changes in total MVPA (hazard ratio 0.97 [95% CI 0.95, 0.99]) and MVPA accumulated in ≥10-min bouts (hazard ratio 0.95 [95% CI 0.91, 0.98]), with a similar pattern for secondary CVD outcomes. Change in accelerometry-measured MVPA at 1 year and self-reported change in physical activity at 1 and 4 years were not associated with CVD outcomes.CONCLUSIONS: Increased accelerometry-measured MVPA from baseline to year 4 is associated with decreased risk of CVD outcomes. This suggests the need for long-term engagement in MVPA to reduce the risk of CVD in adults with overweight/obesity and type 2 diabetes.",
keywords = "Accelerometry, Adult, Cardiovascular Diseases/epidemiology, Diabetes Mellitus, Type 2/epidemiology, Exercise, Humans, Self Report",
author = "{Look AHEAD Study Group} and Jakicic, {John M} and Berkowitz, {Robert I} and Paula Bolin and Bray, {George A} and Clark, {Jeanne M} and Mace Coday and Caitlin Egan and Mary Evans and Foreyt, {John P} and Fulton, {Janet E} and Greenway, {Frank L} and Gregg, {Edward W} and Hazuda, {Helen P} and Hill, {James O} and Horton, {Edward S} and Hubbard, {Van S} and Jeffery, {Robert W} and Johnson, {Karen C} and Ruby Johnson and Kahn, {Steven E} and Anne Kure and Wei Lang and Lewis, {Cora E} and Nathan, {David M} and Jennifer Patricio and Anne Peters and Xavier Pi-Sunyer and Henry Pownall and Rejeski, {W Jack} and Monika Safford and Stewart, {Kerry J} and Wadden, {Thomas A} and Walkup, {Michael P} and Wing, {Rena R} and Holly Wyatt",
note = "Funding Information: Funding. This work was funded by the National Institutes of Health (NIH) through cooperative agreements with the National Institute of Diabetes and Digestive and Kidney Diseases: DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, and DK56992. Additional funding was provided by the National Heart, Lung, and Blood Institute, National Institute of Nursing Research, National Center on Minority Health and Health Disparities, NIH Office of Research on Women{\textquoteright}s Health, and the Centers for Disease Control and Prevention. This research was supported in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. The Indian Health Service provided personnel, medical oversight, and use of facilities. Additional support was received from The Johns Hopkins Medical Institutions Bayview General Clinical Research Center (NIH) (M01RR02719), the Massachusetts General Hospital Mallinckrodt General Clinical Research Center and the Massachusetts Institute of Technology General Clinical Research Center (M01RR01066), the Harvard Clinical and Translational Science Center (RR025758-04), the University of Colorado Health Sciences Center General Clinical Research Center (M01RR00051) and Clinical Nutrition Research Unit (P30 DK48520), the University of Tennessee at Memphis General Clinical Research Center (M01RR0021140), the University of Pittsburgh General Clinical Research Center (M01R R000056), the Clinical Translational Research Center funded by the Clinical and Translational Science Award (UL1 RR 024153) and NIH grant DK046204, the VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs, and the Frederic C. Bartter General Clinical Research Center (M01RR01346). The following organizations have committed to make major contributions to Look AHEAD: FedEx Corporation, Health Management Resources, Funding Information: This work was funded by the National Institutes of Health (NIH) through cooperative agreements with the National Institute of Diabetes and Digestive and Kidney Diseases: DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, and DK56992. Additional funding was provided by the National Heart, Lung, and Blood Institute, National Institute of Nursing Research, National Center on Minority Health and Health Disparities, NIH Office of Research on Women{\textquoteright}s Health,and the Centers for Disease Control and Prevention. This research was supported in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. The Indian Health Service provided personnel, medical oversight, and use of facilities. Additional support was received from The Johns Hopkins Medical Institutions Bayview General Clinical Research Center (NIH) (M01RR02719), the Massachusetts General Hospital Mallinckrodt General Clinical Research Center and the Massachusetts Institute of Technology General Clinical Research Center (M01RR01066), the Harvard Clinical and Translational Science Center (RR025758-04), the University of Colorado Health Sciences Center General Clinical Research Center (M01RR00051) and Clinical Nutrition Research Unit (P30 DK48520), the University of Tennes-see at Memphis General Clinical Research Center (M01RR0021140), the University of Pitts-burgh General Clinical Research Center (M01R R000056), the Clinical Translational Research Center funded by the Clinical and Translational Science Award (UL1 RR 024153) and NIH grant DK046204, the VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs, and the Frederic C. Bartter General Clinical Research Center (M01RR01346). The following organizations have committed to make major contributions to Look AHEAD: FedEx Corporation, Health Management Resources, LifeScan, Inc., a Johnson & Johnson Company, OPTIFAST of Nestle HealthCare Nutrition, Inc., Hoffmann-La Roche Inc., Abbott Nutrition, and Slim-Fast Brand of Unilever North America. A.P. received donated devices from Abbott Diabetes Care. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The opinions expressed in this article are those of the authors and do not necessarily reflect the views of the Indian Health Service or other funding sources. Publisher Copyright: {\textcopyright} 2022, American Diabetes Association Inc.. All rights reserved.",
year = "2022",
month = mar,
day = "1",
doi = "10.2337/dc21-1206",
language = "English (US)",
volume = "45",
pages = "742--749",
journal = "Diabetes care",
issn = "0149-5992",
publisher = "American Diabetes Association Inc.",
number = "3",
}