Association between status epilepticus and cardiorespiratory comorbidity in patients with epilepsy: A population-based study

Purpose: This study aimed to evaluate the relationship between status epilepticus (SE) and cardiorespiratory comorbidity in patients with epilepsy. Methods: We conducted a population-based study using cloud-based aggregated electronic medical records from >53 million patients in the US (Explorys, IBM Watson; January 1999 to November 2020). During the study period, we identified patients with epilepsy with SE. Patients with a history of cardiac arrest, anoxic encephalopathy, and/or cerebrovascular disease were excluded. We reported the prevalences and prevalence ratios of cardiorespiratory and medical comorbidities using age- and sex-adjusted standardization. Results: We identified 494,790 patients with epilepsy and 19,190 had SE. Cardiovascular and respiratory diseases were statistically significantly more prevalent in patients with epilepsy with SE than in those without SE (adjusted prevalence ratio (APR) 1.13, prevalence 68.7% [95% confidence interval (CI): 67.6–69.9] vs 60.9% [95% CI: 60.7–61.1]) and (APR 1.25, 73.1% [95% CI: 71.8–74.3] vs 58.4% [95% CI: 58.1–58.6]), respectively. Aspiration pneumonia (APR 3.12, 0.47% [95% CI: 0.37–0.57] vs 0.15% [95% CI: 0.14–0.16]) and acute respiratory distress syndrome (APR 2.40, 0.47% [95% CI: 0.37–0.57] vs 0.20% [95% CI: 0.18–0.21]) were more prevalent in patients with epilepsy with SE. Common cardiovascular risk factors such as diabetes mellitus (APR 1.13, 17.1% [95% CI: 16.5–17.6] vs 15.1% [95% CI: 1.50–15.2]) and hypertension (APR 1.28, 10.6% [95% CI: 10.2–11.0] vs 8.31% [95% CI: 8.23–8.39]) were also more common in patients with epilepsy with SE. Conclusion: In this population-based study, patients with epilepsy with SE had a statistically significantly higher prevalence of cardiorespiratory comorbidities than in those without SE.