Astrocytes and disease: a neurodevelopmental perspectiv

Anna V Molofsky; Robert Krencik; Erik M Ullian; Erik Ullian; Hui-hsin Tsai; Benjamin Deneen; William D Richardson; Ben A Barres; David H Rowitch

doi:10.1101/gad.188326.112

Astrocytes and disease: a neurodevelopmental perspectiv

Anna V Molofsky, Robert Krencik, Erik M Ullian, Erik Ullian, Hui-hsin Tsai, Benjamin Deneen, William D Richardson, Ben A Barres, David H Rowitch

Research Institute

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531 Scopus citations

Abstract

Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies indicate that astrocytes are morphologically and functionally diverse and play critical roles in neurodevelopmental diseases such as Rett syndrome and fragile X mental retardation. This review summarizes recent advances in astrocyte development, including the role of neural tube patterning in specification and developmental functions of astrocytes during synaptogenesis. We propose here that a precise understanding of astrocyte development is critical to defining heterogeneity and could lead advances in understanding and treating a variety of neuropsychiatric diseases.

Original language	English (US)
Pages (from-to)	891-907
Number of pages	17
Journal	Genes & development
Volume	26
Issue number	9
DOIs	https://doi.org/10.1101/gad.188326.112
State	Published - May 1 2012

Keywords

Astrocytes
Heredodegenerative Disorders, Nervous System
Humans
Mental Disorders
Neural Stem Cells
Neurogenesis
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

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AU - Molofsky, Anna V

AU - Krencik, Robert

AU - Ullian, Erik M

AU - Ullian, Erik

AU - Tsai, Hui-hsin

AU - Deneen, Benjamin

AU - Richardson, William D

AU - Barres, Ben A

AU - Rowitch, David H

PY - 2012/5/1

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KW - Astrocytes

KW - Heredodegenerative Disorders, Nervous System

KW - Humans

KW - Mental Disorders

KW - Neural Stem Cells

KW - Neurogenesis

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Review

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DO - 10.1101/gad.188326.112

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SN - 0890-9369

VL - 26

SP - 891

EP - 907

JO - Genes & development

JF - Genes & development

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Astrocytes and disease: a neurodevelopmental perspectiv

Abstract

Keywords

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