@inbook{d0d1ac0186e542da9f5bf1fc902b538e,
title = "Autophagy in chronic lung disease",
abstract = "The development of chronic lung disease occurs as a consequence of multiple cellular events that involve an initial insult which often leads to the development of chronic inflammation, and the dysregulation of cellular proliferation and cell death mechanisms. Multiple cell types in the lung are key to the respiratory and protective/barrier functions necessary to manage the chronic exposures to environmental, mechanical, and oxidative stressors. Autophagy is essential to lung development and homeostasis, as well as the prevention and development of disease. The cellular process involves the collection and removal of unwanted organelles and proteins through lysosomal degradation. In recent years, investigations have addressed the roles of autophagy and selective autophagy in numerous chronic lung diseases. Here, we highlight recent advances on the role of autophagy in the pathogenesis of asthma, chronic obstructive pulmonary disease and emphysema, pulmonary arterial hypertension, and idiopathic pulmonary fibrosis.",
keywords = "Asthma, Autophagy, COPD, Emphysema, Idiopathic pulmonary fibrosis, Pulmonary hypertension",
author = "Racanelli, {Alexandra C.} and Choi, {Augustine M.K.} and Choi, {Mary E.}",
note = "Funding Information: M.E.C. and A.M.K.C. are supported by National Institutes of Health (NIH) R01 HL132198, R01 HL133801, R01 HL055330, and R01 HL060234. A.C.R. is supported by NIH T32HL134629. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
doi = "10.1016/bs.pmbts.2020.02.001",
language = "English (US)",
isbn = "9780128220214",
volume = "172",
series = "Progress in molecular biology and translational science",
publisher = "Elsevier B.V.",
pages = "135--156",
editor = "Martinez, {Aitziber Buqu{\'e}} and Lorenzo Galluzzi",
booktitle = "Autophagy in health and disease",
}