Autophagy in major human diseases

Daniel J. Klionsky; Giulia Petroni; Ravi K. Amaravadi; Eric H. Baehrecke; Andrea Ballabio; Patricia Boya; José Manuel Bravo-San Pedro; Ken Cadwell; Francesco Cecconi; Augustine M.K. Choi; Mary E. Choi; Charleen T. Chu; Patrice Codogno; Maria Isabel Colombo; Ana Maria Cuervo; Vojo Deretic; Ivan Dikic; Zvulun Elazar; Eeva Liisa Eskelinen; Gian Maria Fimia; David A. Gewirtz; Douglas R. Green; Malene Hansen; Marja Jäättelä; Terje Johansen; Gábor Juhász; Vassiliki Karantza; Claudine Kraft; Guido Kroemer; Nicholas T. Ktistakis; Sharad Kumar; Carlos Lopez-Otin; Kay F. Macleod; Frank Madeo; Jennifer Martinez; Alicia Meléndez; Noboru Mizushima; Christian Münz; Josef M. Penninger; Rushika M Perera; Mauro Piacentini; Fulvio Reggiori; David C. Rubinsztein; Kevin M Ryan; Junichi Sadoshima; Laura Santambrogio; Luca Scorrano; Hans Uwe Simon; Anna Katharina Simon; Anne Simonsen; Alexandra Stolz; Nektarios Tavernarakis; Sharon A. Tooze; Tamotsu Yoshimori; Junying Yuan; Zhenyu Yue; Qing Zhong; Lorenzo Galluzzi; Federico Pietrocola

doi:10.15252/embj.2021108863

Autophagy in major human diseases

Daniel J. Klionsky, Giulia Petroni, Ravi K. Amaravadi, Eric H. Baehrecke, Andrea Ballabio, Patricia Boya, José Manuel Bravo-San Pedro, Ken Cadwell, Francesco Cecconi, Augustine M.K. Choi, Mary E. Choi, Charleen T. Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Vojo Deretic, Ivan Dikic, Zvulun Elazar, Eeva Liisa Eskelinen, Gian Maria FimiaDavid A. Gewirtz, Douglas R. Green, Malene Hansen, Marja Jäättelä, Terje Johansen, Gábor Juhász, Vassiliki Karantza, Claudine Kraft, Guido Kroemer, Nicholas T. Ktistakis, Sharad Kumar, Carlos Lopez-Otin, Kay F. Macleod, Frank Madeo, Jennifer Martinez, Alicia Meléndez, Noboru Mizushima, Christian Münz, Josef M. Penninger, Rushika M Perera, Mauro Piacentini, Fulvio Reggiori, David C. Rubinsztein, Kevin M Ryan, Junichi Sadoshima, Laura Santambrogio, Luca Scorrano, Hans Uwe Simon, Anna Katharina Simon, Anne Simonsen, Alexandra Stolz, Nektarios Tavernarakis, Sharon A. Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Lorenzo Galluzzi, Federico Pietrocola

Research output: Contribution to journal › Review article › peer-review

608 Scopus citations

Abstract

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

Original language	English (US)
Article number	e108863
Journal	EMBO Journal
Volume	40
Issue number	19
DOIs	https://doi.org/10.15252/embj.2021108863
State	Published - Oct 1 2021

Keywords

aging
cancer
inflammation
metabolic syndromes
neurodegeneration

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.15252/embj.2021108863

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Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo-San Pedro, J. M., Cadwell, K., Cecconi, F., Choi, A. M. K., Choi, M. E., Chu, C. T., Codogno, P., Colombo, MI., Cuervo, A. M., Deretic, V., Dikic, I., Elazar, Z., Eskelinen, E. L., ... Pietrocola, F. (2021). Autophagy in major human diseases. EMBO Journal, 40(19), Article e108863. https://doi.org/10.15252/embj.2021108863

Klionsky, DJ, Petroni, G, Amaravadi, RK, Baehrecke, EH, Ballabio, A, Boya, P, Bravo-San Pedro, JM, Cadwell, K, Cecconi, F, Choi, AMK, Choi, ME, Chu, CT, Codogno, P, Colombo, MI, Cuervo, AM, Deretic, V, Dikic, I, Elazar, Z, Eskelinen, EL, Fimia, GM, Gewirtz, DA, Green, DR, Hansen, M, Jäättelä, M, Johansen, T, Juhász, G, Karantza, V, Kraft, C, Kroemer, G, Ktistakis, NT, Kumar, S, Lopez-Otin, C, Macleod, KF, Madeo, F, Martinez, J, Meléndez, A, Mizushima, N, Münz, C, Penninger, JM, Perera, RM, Piacentini, M, Reggiori, F, Rubinsztein, DC, Ryan, KM, Sadoshima, J, Santambrogio, L, Scorrano, L, Simon, HU, Simon, AK, Simonsen, A, Stolz, A, Tavernarakis, N, Tooze, SA, Yoshimori, T, Yuan, J, Yue, Z, Zhong, Q, Galluzzi, L & Pietrocola, F 2021, 'Autophagy in major human diseases', EMBO Journal, vol. 40, no. 19, e108863. https://doi.org/10.15252/embj.2021108863

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title = "Autophagy in major human diseases",

abstract = "Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.",

keywords = "aging, cancer, inflammation, metabolic syndromes, neurodegeneration",

author = "Klionsky, {Daniel J.} and Giulia Petroni and Amaravadi, {Ravi K.} and Baehrecke, {Eric H.} and Andrea Ballabio and Patricia Boya and {Bravo-San Pedro}, {Jos{\'e} Manuel} and Ken Cadwell and Francesco Cecconi and Choi, {Augustine M.K.} and Choi, {Mary E.} and Chu, {Charleen T.} and Patrice Codogno and Maria Isabel Colombo and Cuervo, {Ana Maria} and Vojo Deretic and Ivan Dikic and Zvulun Elazar and Eskelinen, {Eeva Liisa} and Fimia, {Gian Maria} and Gewirtz, {David A.} and Green, {Douglas R.} and Malene Hansen and Marja J{\"a}{\"a}ttel{\"a} and Terje Johansen and G{\'a}bor Juh{\'a}sz and Vassiliki Karantza and Claudine Kraft and Guido Kroemer and Ktistakis, {Nicholas T.} and Sharad Kumar and Carlos Lopez-Otin and Macleod, {Kay F.} and Frank Madeo and Jennifer Martinez and Alicia Mel{\'e}ndez and Noboru Mizushima and Christian M{\"u}nz and Penninger, {Josef M.} and Rushika M Perera and Mauro Piacentini and Fulvio Reggiori and Rubinsztein, {David C.} and Kevin M Ryan and Junichi Sadoshima and Laura Santambrogio and Luca Scorrano and Simon, {Hans Uwe} and Simon, {Anna Katharina} and Anne Simonsen and Alexandra Stolz and Nektarios Tavernarakis and Tooze, {Sharon A.} and Tamotsu Yoshimori and Junying Yuan and Zhenyu Yue and Qing Zhong and Lorenzo Galluzzi and Federico Pietrocola",

note = "Funding Information: A.B. is cofounder of CASMA Therapeutics Inc., Advisory Board member of Next Generation Diagnostics and of Avilar Therapeutics. K.C. has received research support from Pfizer, Takeda, Pacific Biosciences, and AbbVie; consulted for or received an honorarium from PureTech Health, Genentech, and AbbVie; and holds U.S. patent 10,722,600 and provisional patents 62/935,035 and 63/157,225. A.M.K.C. is a cofounder, stock holder and serves on the Scientific Advisory Board for Proterris, which develops therapeutic uses for carbon monoxide. A.M.K.C. also has a use patent on CO. G.K is a cofounder and advisor of EverImmune, Samsara Therapeutics, and Therafast Bio as well as advisor for The Longevity Labs (TLL). F.M. is a founder, is advisor, and has equity interests in The Longevity Labs (TLL) and Samara Therapeutics. D.C.R is a consultant for Aladdin Healthcare Technologies SE, Drishti Discoveries, and Nido Biosciences. L.G. has received research funding from Lytix Biopharma and Phosplatin, as well as consulting/advisory honoraria from Boehringer Ingelheim, AstraZeneca, OmniSEQ, Onxeo, The Longevity Labs, Inzen, and the Luke Heller TECPR2 Foundation. RKA is cofounder of Pinpoint Therapeutics and advisor for Deciphera, Sprint Biosciences, Merck, and Immunacell. He gets research funding for clinical trials from Novartis, Bristol Myers Squibb, Pfizer, and Deciphera. J.Y. is a consultant for Denali Therapeutics, Sanofi, and Nido. All other authors have no conflicts of interest to disclose. Publisher Copyright: {\textcopyright} 2021 The Authors. Published under the terms of the CC BY 4.0 license",

year = "2021",

month = oct,

day = "1",

doi = "10.15252/embj.2021108863",

language = "English (US)",

volume = "40",

journal = "EMBO Journal",

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number = "19",

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T1 - Autophagy in major human diseases

AU - Klionsky, Daniel J.

AU - Petroni, Giulia

AU - Amaravadi, Ravi K.

AU - Baehrecke, Eric H.

AU - Ballabio, Andrea

AU - Boya, Patricia

AU - Bravo-San Pedro, José Manuel

AU - Cadwell, Ken

AU - Cecconi, Francesco

AU - Choi, Augustine M.K.

AU - Choi, Mary E.

AU - Chu, Charleen T.

AU - Codogno, Patrice

AU - Colombo, Maria Isabel

AU - Cuervo, Ana Maria

AU - Deretic, Vojo

AU - Dikic, Ivan

AU - Elazar, Zvulun

AU - Eskelinen, Eeva Liisa

AU - Fimia, Gian Maria

AU - Gewirtz, David A.

AU - Green, Douglas R.

AU - Hansen, Malene

AU - Jäättelä, Marja

AU - Johansen, Terje

AU - Juhász, Gábor

AU - Karantza, Vassiliki

AU - Kraft, Claudine

AU - Kroemer, Guido

AU - Ktistakis, Nicholas T.

AU - Kumar, Sharad

AU - Lopez-Otin, Carlos

AU - Macleod, Kay F.

AU - Madeo, Frank

AU - Martinez, Jennifer

AU - Meléndez, Alicia

AU - Mizushima, Noboru

AU - Münz, Christian

AU - Penninger, Josef M.

AU - Perera, Rushika M

AU - Piacentini, Mauro

AU - Reggiori, Fulvio

AU - Rubinsztein, David C.

AU - Ryan, Kevin M

AU - Sadoshima, Junichi

AU - Santambrogio, Laura

AU - Scorrano, Luca

AU - Simon, Hans Uwe

AU - Simon, Anna Katharina

AU - Simonsen, Anne

AU - Stolz, Alexandra

AU - Tavernarakis, Nektarios

AU - Tooze, Sharon A.

AU - Yoshimori, Tamotsu

AU - Yuan, Junying

AU - Yue, Zhenyu

AU - Zhong, Qing

AU - Galluzzi, Lorenzo

AU - Pietrocola, Federico

N1 - Funding Information: A.B. is cofounder of CASMA Therapeutics Inc., Advisory Board member of Next Generation Diagnostics and of Avilar Therapeutics. K.C. has received research support from Pfizer, Takeda, Pacific Biosciences, and AbbVie; consulted for or received an honorarium from PureTech Health, Genentech, and AbbVie; and holds U.S. patent 10,722,600 and provisional patents 62/935,035 and 63/157,225. A.M.K.C. is a cofounder, stock holder and serves on the Scientific Advisory Board for Proterris, which develops therapeutic uses for carbon monoxide. A.M.K.C. also has a use patent on CO. G.K is a cofounder and advisor of EverImmune, Samsara Therapeutics, and Therafast Bio as well as advisor for The Longevity Labs (TLL). F.M. is a founder, is advisor, and has equity interests in The Longevity Labs (TLL) and Samara Therapeutics. D.C.R is a consultant for Aladdin Healthcare Technologies SE, Drishti Discoveries, and Nido Biosciences. L.G. has received research funding from Lytix Biopharma and Phosplatin, as well as consulting/advisory honoraria from Boehringer Ingelheim, AstraZeneca, OmniSEQ, Onxeo, The Longevity Labs, Inzen, and the Luke Heller TECPR2 Foundation. RKA is cofounder of Pinpoint Therapeutics and advisor for Deciphera, Sprint Biosciences, Merck, and Immunacell. He gets research funding for clinical trials from Novartis, Bristol Myers Squibb, Pfizer, and Deciphera. J.Y. is a consultant for Denali Therapeutics, Sanofi, and Nido. All other authors have no conflicts of interest to disclose. Publisher Copyright: © 2021 The Authors. Published under the terms of the CC BY 4.0 license

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

AB - Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

KW - aging

KW - cancer

KW - inflammation

KW - metabolic syndromes

KW - neurodegeneration

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U2 - 10.15252/embj.2021108863

DO - 10.15252/embj.2021108863

M3 - Review article

C2 - 34459017

AN - SCOPUS:85113807620

SN - 0261-4189

VL - 40

JO - EMBO Journal

JF - EMBO Journal

IS - 19

M1 - e108863

ER -

Autophagy in major human diseases

Abstract

Keywords

ASJC Scopus subject areas

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