TY - JOUR
T1 - Biocompatibility assessment of Si-based nano- and micro-particles
AU - Jaganathan, Hamsa
AU - Godin, Biana
N1 - Funding Information:
We would like to thank Srimeenakshi Srinivasan and Fransisca Leonard for their informative discussions on the manuscript. We also would like to thank Matthew Landry for his assistance with graphics in the manuscript. The authors acknowledge a financial support from the following sources: Susan G. Komen Postdoctoral Fellowship # PDF12229449 , NIH U54CA143837 (CTO, PS-OC), NIH 1U54CA151668-01 (TCCN, CCNE), DOD W81XWH-09-1-0212 and DOD W81XWH-11-02-0168 .
PY - 2012/12
Y1 - 2012/12
N2 - Silicon is one of the most abundant chemical elements found on the Earth. Due to its unique chemical and physical properties, silicon based materials and their oxides (e.g. silica) have been used in several industries such as building and construction, electronics, food industry, consumer products and biomedical engineering/medicine. This review summarizes studies on effects of silicon and silica nano- and micro-particles on cells and organs following four main exposure routes, namely, intravenous, pulmonary, dermal and oral. Further, possible genotoxic effects of silica based nanoparticles are discussed. The review concludes with an outlook on improving and standardizing biocompatibility assessment for nano- and micro-particles.
AB - Silicon is one of the most abundant chemical elements found on the Earth. Due to its unique chemical and physical properties, silicon based materials and their oxides (e.g. silica) have been used in several industries such as building and construction, electronics, food industry, consumer products and biomedical engineering/medicine. This review summarizes studies on effects of silicon and silica nano- and micro-particles on cells and organs following four main exposure routes, namely, intravenous, pulmonary, dermal and oral. Further, possible genotoxic effects of silica based nanoparticles are discussed. The review concludes with an outlook on improving and standardizing biocompatibility assessment for nano- and micro-particles.
KW - Biocompatibility
KW - Mesoporous
KW - Nanomaterials
KW - Silica
KW - Silicon
KW - Toxicity
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U2 - 10.1016/j.addr.2012.05.008
DO - 10.1016/j.addr.2012.05.008
M3 - Review article
C2 - 22634160
AN - SCOPUS:84869155482
SN - 0169-409X
VL - 64
SP - 1800
EP - 1819
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
IS - 15
ER -