Biological microniches characterizing pathological lesions. Impact on nanoparticle-based delivery of therapeutics.

Ismail M. Meraz; Victor Segura-Ibarra; Fransisca Leonard; Javier Gonzalez; Sally Ally; Biana Godin; Rita Serda

doi:10.1016/B978-0-08-098338-7.00006-6

Biological microniches characterizing pathological lesions. Impact on nanoparticle-based delivery of therapeutics.

Ismail M. Meraz, Victor Segura-Ibarra, Fransisca Leonard, Javier Gonzalez, Sally Ally, Biana Godin, Rita Serda

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Discrete pathologies have unique features that contribute to disease progression. Each lesion contains unique clusters of cells and other factors that make up specific micro-niches. Individual microniches present novel barriers that hamper the delivery of therapeutics, but it also contains characteristic elements that can favour accumulation of therapeutics within the lesion. This chapter discusses the unique biology associated with cancer, cardiovascular disease, and neurological disorders and describes how each unique presentation can be used to optimize nanoparticle design for targeting the lesion.

Original language	English
Pages (from-to)	139-173
Number of pages	35
Journal	Frontiers of Nanoscience
Volume	5
DOIs	https://doi.org/10.1016/B978-0-08-098338-7.00006-6
State	Published - Sep 25 2013

Keywords

Biological barrier
Cancer
Cardiovascular disease
Drug delivery
Immunotherapy
Microenvironment
Nanoparticle
Neurology disorder

ASJC Scopus subject areas

Materials Science(all)
Biomedical Engineering
Bioengineering

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10.1016/B978-0-08-098338-7.00006-6

Cite this

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title = "Biological microniches characterizing pathological lesions. Impact on nanoparticle-based delivery of therapeutics.",

abstract = "Discrete pathologies have unique features that contribute to disease progression. Each lesion contains unique clusters of cells and other factors that make up specific micro-niches. Individual microniches present novel barriers that hamper the delivery of therapeutics, but it also contains characteristic elements that can favour accumulation of therapeutics within the lesion. This chapter discusses the unique biology associated with cancer, cardiovascular disease, and neurological disorders and describes how each unique presentation can be used to optimize nanoparticle design for targeting the lesion.",

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AU - Meraz, Ismail M.

AU - Segura-Ibarra, Victor

AU - Leonard, Fransisca

AU - Gonzalez, Javier

AU - Ally, Sally

AU - Godin, Biana

AU - Serda, Rita

PY - 2013/9/25

Y1 - 2013/9/25

N2 - Discrete pathologies have unique features that contribute to disease progression. Each lesion contains unique clusters of cells and other factors that make up specific micro-niches. Individual microniches present novel barriers that hamper the delivery of therapeutics, but it also contains characteristic elements that can favour accumulation of therapeutics within the lesion. This chapter discusses the unique biology associated with cancer, cardiovascular disease, and neurological disorders and describes how each unique presentation can be used to optimize nanoparticle design for targeting the lesion.

AB - Discrete pathologies have unique features that contribute to disease progression. Each lesion contains unique clusters of cells and other factors that make up specific micro-niches. Individual microniches present novel barriers that hamper the delivery of therapeutics, but it also contains characteristic elements that can favour accumulation of therapeutics within the lesion. This chapter discusses the unique biology associated with cancer, cardiovascular disease, and neurological disorders and describes how each unique presentation can be used to optimize nanoparticle design for targeting the lesion.

KW - Biological barrier

KW - Cancer

KW - Cardiovascular disease

KW - Drug delivery

KW - Immunotherapy

KW - Microenvironment

KW - Nanoparticle

KW - Neurology disorder

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JO - Frontiers of Nanoscience

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ER -

Biological microniches characterizing pathological lesions. Impact on nanoparticle-based delivery of therapeutics.

Abstract

Keywords

ASJC Scopus subject areas

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