Abstract
Stem cell-based therapeutics show promise for treatment of vascular diseases. However, the survival of the cells after in vivo injection into diseased tissues remains a concern. In the advent of non-invasive optical imaging techniques such as bioluminescence imaging (BLI), cell locali-zation and survival can be easily monitored over time. This approach has recently been applied towards monitoring stem cell treatments for vascular regeneration of the coronary or pe-ripheral arteries. In this review, we will describe the application of BLI for tracking trans-planted stem cells and associating their viability with therapeutic efficacy, in preclinical disease models of vascular disease.
Original language | English (US) |
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Pages (from-to) | 346-354 |
Number of pages | 9 |
Journal | Theranostics |
Volume | 2 |
Issue number | 4 |
DOIs | |
State | Published - 2012 |
Keywords
- Bioluminescence
- Embryonic stem cell
- Induced pluripotent stem cell
- Myocardial infarction
- Peripheral arterial disease
- Vascular regeneration
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)