TY - JOUR
T1 - Biomineralization
T2 - A new tool for developing eco-sustainable Ti-doped hydroxyapatite-based hybrid UV filters
AU - Campodoni, Elisabetta
AU - Montanari, Margherita
AU - Artusi, Chiara
AU - Bergamini, Linda
AU - Bassi, Giada
AU - Destro, Elena
AU - Fenoglio, Ivana
AU - Panseri, Silvia
AU - Tampieri, Anna
AU - Sanson, Alessandra
AU - Sandri, Monica
N1 - Funding Information:
This project has received funding from the Project PoC2020-ProtecTHA “Innovative UV filters for safer and more eco-sustainable sun protection” Co-financed from MiSE and CNR .
Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/8
Y1 - 2023/8
N2 - It is well known that the prolonged exposure to UV radiation from sunlight can compromise human health and is particularly damaging to the skin, leading to sunburn, photo-aging and skin cancer. Sunscreen formulations containing UV-filters present a barrier against solar UV and help to mitigate the harmful effects however, concern about their safety for both human and environmental health is still a much-debated topic. EC regulations classify UV-filters depending on their chemical nature, particle size, and mechanism of action. Furthermore, it regulates their use in cosmetic products with specific limitations in terms of concentration (organic UV filters) and particle size and surface modification to reduce their photo-activity (mineral UV filters). The regulations have prompted researchers to identify new materials that show promise for use in sunscreens. In this work, biomimetic hybrid materials composed of titanium-doped hydroxyapatite (TiHA) grown on two different organic templates, derived from animal (gelatin - from pig skin) and vegetable (alginate - from algae) sources. These novel materials were developed and characterized to obtain sustainable UV-filters as a safer alternative for both human and ecosystem health. This ‘biomineralization’ process yielded TiHA nanoparticles that demonstrated high UV reflectance, low photoactivity, good biocompatibility and an aggregate morphology which prevents dermal penetration. The materials are safe for topical application and for the marine environment; moreover, they can protect organic sunscreen components from photodegradation and yield long-lasting protection.
AB - It is well known that the prolonged exposure to UV radiation from sunlight can compromise human health and is particularly damaging to the skin, leading to sunburn, photo-aging and skin cancer. Sunscreen formulations containing UV-filters present a barrier against solar UV and help to mitigate the harmful effects however, concern about their safety for both human and environmental health is still a much-debated topic. EC regulations classify UV-filters depending on their chemical nature, particle size, and mechanism of action. Furthermore, it regulates their use in cosmetic products with specific limitations in terms of concentration (organic UV filters) and particle size and surface modification to reduce their photo-activity (mineral UV filters). The regulations have prompted researchers to identify new materials that show promise for use in sunscreens. In this work, biomimetic hybrid materials composed of titanium-doped hydroxyapatite (TiHA) grown on two different organic templates, derived from animal (gelatin - from pig skin) and vegetable (alginate - from algae) sources. These novel materials were developed and characterized to obtain sustainable UV-filters as a safer alternative for both human and ecosystem health. This ‘biomineralization’ process yielded TiHA nanoparticles that demonstrated high UV reflectance, low photoactivity, good biocompatibility and an aggregate morphology which prevents dermal penetration. The materials are safe for topical application and for the marine environment; moreover, they can protect organic sunscreen components from photodegradation and yield long-lasting protection.
KW - Biomimetic materials
KW - Biomineralization
KW - Eco-sustainability
KW - Photostability
KW - Physical filters
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U2 - 10.1016/j.bioadv.2023.213474
DO - 10.1016/j.bioadv.2023.213474
M3 - Article
AN - SCOPUS:85159353830
SN - 2772-9508
VL - 151
JO - Biomaterials Advances
JF - Biomaterials Advances
M1 - 213474
ER -