Biosynthesis of 18‐Hydroxytestosterone in the Human Foetal Liver

B. P. Lisboa; J. Gustafsson

doi:10.1111/j.1432-1033.1969.tb00622.x

Biosynthesis of 18‐Hydroxytestosterone in the Human Foetal Liver

B. P. Lisboa, J. Gustafsson

Research Institute

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Abstract

After incubation of testosterone with 105 000 X g microsomes of human foetal liver, a C₁₉ steroid with a 3‐oxo‐Δ⁴‐structure was isolated by ascending one‐dimensional thin‐layer chromatography. Gas chromatography‐mass spectrometry revealed that the compound was identical with 18‐hydroxytestosterone. The significance of this finding in relation to earlier reports of 18‐hydroxylated steroids in human urine is discussed.

Original language	English (US)
Pages (from-to)	402-405
Number of pages	4
Journal	European Journal of Biochemistry
Volume	9
Issue number	3
DOIs	https://doi.org/10.1111/j.1432-1033.1969.tb00622.x
State	Published - Jun 1969

ASJC Scopus subject areas

Biochemistry

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10.1111/j.1432-1033.1969.tb00622.x

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title = "Biosynthesis of 18‐Hydroxytestosterone in the Human Foetal Liver",

abstract = "After incubation of testosterone with 105 000 X g microsomes of human foetal liver, a C19 steroid with a 3‐oxo‐Δ4‐structure was isolated by ascending one‐dimensional thin‐layer chromatography. Gas chromatography‐mass spectrometry revealed that the compound was identical with 18‐hydroxytestosterone. The significance of this finding in relation to earlier reports of 18‐hydroxylated steroids in human urine is discussed.",

author = "Lisboa, {B. P.} and J. Gustafsson",

year = "1969",

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doi = "10.1111/j.1432-1033.1969.tb00622.x",

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AU - Lisboa, B. P.

AU - Gustafsson, J.

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AB - After incubation of testosterone with 105 000 X g microsomes of human foetal liver, a C19 steroid with a 3‐oxo‐Δ4‐structure was isolated by ascending one‐dimensional thin‐layer chromatography. Gas chromatography‐mass spectrometry revealed that the compound was identical with 18‐hydroxytestosterone. The significance of this finding in relation to earlier reports of 18‐hydroxylated steroids in human urine is discussed.

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ER -

Biosynthesis of 18‐Hydroxytestosterone in the Human Foetal Liver

Abstract

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