Biosynthesis of 6β‐ and 6α‐Hydroxyprogesterone in the Human Foetal Liver

B. P. Lisboa; J. Gustafsson

doi:10.1111/j.1432-1033.1969.tb00637.x

Biosynthesis of 6β‐ and 6α‐Hydroxyprogesterone in the Human Foetal Liver

B. P. Lisboa, J. Gustafsson

Research Institute

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Abstract

After incubation of progesterone with 105000 Xg microsomes of human foetal liver two C₂₁O₃ steroids were isolated by ascending one‐dimensional thin‐layer chromatography. Gas chromato‐graphy‐mass spectrometry analysis showed that the compounds were identical with 6β‐ and 6α‐hydroxyprogesterone. The significance of this finding in relation to earlier reports of 6‐hy‐droxylated C₂₁ steroids in human pregnancy urine is discussed.

Original language	English (US)
Pages (from-to)	503-506
Number of pages	4
Journal	European Journal of Biochemistry
Volume	9
Issue number	4
DOIs	https://doi.org/10.1111/j.1432-1033.1969.tb00637.x
State	Published - Jul 1969

ASJC Scopus subject areas

Biochemistry

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10.1111/j.1432-1033.1969.tb00637.x

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title = "Biosynthesis of 6β‐ and 6α‐Hydroxyprogesterone in the Human Foetal Liver",

abstract = "After incubation of progesterone with 105000 Xg microsomes of human foetal liver two C21O3 steroids were isolated by ascending one‐dimensional thin‐layer chromatography. Gas chromato‐graphy‐mass spectrometry analysis showed that the compounds were identical with 6β‐ and 6α‐hydroxyprogesterone. The significance of this finding in relation to earlier reports of 6‐hy‐droxylated C21 steroids in human pregnancy urine is discussed.",

author = "Lisboa, {B. P.} and J. Gustafsson",

year = "1969",

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doi = "10.1111/j.1432-1033.1969.tb00637.x",

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T1 - Biosynthesis of 6β‐ and 6α‐Hydroxyprogesterone in the Human Foetal Liver

AU - Lisboa, B. P.

AU - Gustafsson, J.

PY - 1969/7

Y1 - 1969/7

N2 - After incubation of progesterone with 105000 Xg microsomes of human foetal liver two C21O3 steroids were isolated by ascending one‐dimensional thin‐layer chromatography. Gas chromato‐graphy‐mass spectrometry analysis showed that the compounds were identical with 6β‐ and 6α‐hydroxyprogesterone. The significance of this finding in relation to earlier reports of 6‐hy‐droxylated C21 steroids in human pregnancy urine is discussed.

AB - After incubation of progesterone with 105000 Xg microsomes of human foetal liver two C21O3 steroids were isolated by ascending one‐dimensional thin‐layer chromatography. Gas chromato‐graphy‐mass spectrometry analysis showed that the compounds were identical with 6β‐ and 6α‐hydroxyprogesterone. The significance of this finding in relation to earlier reports of 6‐hy‐droxylated C21 steroids in human pregnancy urine is discussed.

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Biosynthesis of 6β‐ and 6α‐Hydroxyprogesterone in the Human Foetal Liver

Abstract

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