TY - JOUR
T1 - BMI and pneumonia outcomes in critically ill covid-19 patients
T2 - An international multicenter study
AU - Chetboun, Mikael
AU - Raverdy, Violeta
AU - Labreuche, Julien
AU - Simonnet, Arthur
AU - Wallet, Florent
AU - Caussy, Cyrielle
AU - Antonelli, Massimo
AU - Artigas, Antonio
AU - Goma, Gemma
AU - Meziani, Ferhat
AU - Helms, Julie
AU - Mylonakis, Eleftherios
AU - Levy, Mitchell M.
AU - Kalligeros, Markos
AU - Latronico, Nicola
AU - Piva, Simone
AU - Cerf, Charles
AU - Neuville, Mathilde
AU - Klouche, Kada
AU - Larcher, Romaric
AU - Tamion, Fabienne
AU - Occhiali, Emilie
AU - Snacken, Morgane
AU - Preiser, Jean Charles
AU - Kontar, Loay
AU - Riviere, Antoine
AU - Silva, Stein
AU - Sarton, Benjamine
AU - Krouchi, Raphael
AU - Dubar, Victoria
AU - Palaiodimos, Leonidas
AU - Karamanis, Dimitrios
AU - Perche, Juliette
AU - L'Her, Erwan
AU - Busetto, Luca
AU - Dicker, Dror
AU - Lev, Shaul
AU - Duhamel, Alain
AU - Jourdain, Mercè
AU - Pattou, François
N1 - Funding Information:
Authors thank Mr. Maxime Caillier, Mr. Guillaume Deraedt, and Mr. Amhed Bouzidi for their management of regulatory aspects of the study. Role of the sponsor: The sponsors were represented by the corresponding authors (François Pattou and Mercè Jourdain). The sponsors had a role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and review and approval to submit the manuscript for publication. The sponsors did not have the right to veto submission to any particular journal but did participate in the writing group’s discussion when selecting an appropriate journal for submission. The corresponding authors had the final say in submitting the manuscript for publication.
Publisher Copyright:
© 2021 The Obesity Society
PY - 2021/9
Y1 - 2021/9
N2 - Objective: Previous studies have unveiled a relationship between the severity of coronavirus disease 2019 (COVID-19) pneumonia and obesity. The aims of this multicenter retrospective cohort study were to disentangle the association of BMI and associated metabolic risk factors (diabetes, hypertension, hyperlipidemia, and current smoking status) in critically ill patients with COVID-19. Methods: Patients admitted to intensive care units for COVID-19 in 21 centers (in Europe, Israel, and the United States) were enrolled in this study between February 19, 2020, and May 19, 2020. Primary and secondary outcomes were the need for invasive mechanical ventilation (IMV) and 28-day mortality, respectively. Results: A total of 1,461 patients were enrolled; the median (interquartile range) age was 64 years (40.9-72.0); 73.2% of patients were male; the median BMI was 28.1 kg/m2 (25.4-32.3); a total of 1,080 patients (73.9%) required IMV; and the 28-day mortality estimate was 36.1% (95% CI: 33.0-39.5). An adjusted mixed logistic regression model showed a significant linear relationship between BMI and IMV: odds ratio = 1.27 (95% CI: 1.12-1.45) per 5 kg/m2. An adjusted Cox proportional hazards regression model showed a significant association between BMI and mortality, which was increased only in obesity class III (≥40; hazard ratio = 1.68 [95% CI: 1.06-2.64]). Conclusions: In critically ill COVID-19 patients, a linear association between BMI and the need for IMV, independent of other metabolic risk factors, and a nonlinear association between BMI and mortality risk were observed.
AB - Objective: Previous studies have unveiled a relationship between the severity of coronavirus disease 2019 (COVID-19) pneumonia and obesity. The aims of this multicenter retrospective cohort study were to disentangle the association of BMI and associated metabolic risk factors (diabetes, hypertension, hyperlipidemia, and current smoking status) in critically ill patients with COVID-19. Methods: Patients admitted to intensive care units for COVID-19 in 21 centers (in Europe, Israel, and the United States) were enrolled in this study between February 19, 2020, and May 19, 2020. Primary and secondary outcomes were the need for invasive mechanical ventilation (IMV) and 28-day mortality, respectively. Results: A total of 1,461 patients were enrolled; the median (interquartile range) age was 64 years (40.9-72.0); 73.2% of patients were male; the median BMI was 28.1 kg/m2 (25.4-32.3); a total of 1,080 patients (73.9%) required IMV; and the 28-day mortality estimate was 36.1% (95% CI: 33.0-39.5). An adjusted mixed logistic regression model showed a significant linear relationship between BMI and IMV: odds ratio = 1.27 (95% CI: 1.12-1.45) per 5 kg/m2. An adjusted Cox proportional hazards regression model showed a significant association between BMI and mortality, which was increased only in obesity class III (≥40; hazard ratio = 1.68 [95% CI: 1.06-2.64]). Conclusions: In critically ill COVID-19 patients, a linear association between BMI and the need for IMV, independent of other metabolic risk factors, and a nonlinear association between BMI and mortality risk were observed.
UR - http://www.scopus.com/inward/record.url?scp=85113295755&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85113295755&partnerID=8YFLogxK
U2 - 10.1002/oby.23223
DO - 10.1002/oby.23223
M3 - Article
C2 - 33966355
AN - SCOPUS:85113295755
SN - 1930-7381
VL - 29
SP - 1477
EP - 1486
JO - Obesity
JF - Obesity
IS - 9
ER -