TY - JOUR
T1 - Body composition in Spinocerebellar ataxia type 3 and 10 patients
T2 - Comparative study with control group
AU - Leite, Christiane de M.B.Almeida
AU - Schieferdecker, Maria Eliana M.
AU - Frehner, Caroline
AU - Munhoz, Renato P.
AU - Ashizawa, Tetsuo
AU - Teive, Hélio A.G.
N1 - Funding Information:
Contributors None. Funding Christiane de Mesquita Barros Almeida Leite has received financial support from the Coordination for the Improvement of Higher Education Personnel (CAPES) (grant numbers P. 99999.003674/2014-02; P. BEX 3674/14-2) for granting the scholarship during the exchange program in Tor Vergata University–Rome, Italy. Tetsuo Ashizawa receives research/grant support as a principal investigator of studies for Ionis Pharmaceuticals, Inc. (grant number 1515598769-CS2); the Myotonic Dystrophy Foundation; and the National Institutes of Health (grant number NS083564). Conflicts of interest None. Ethics approval None.
Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/1/2
Y1 - 2020/1/2
N2 - Background: Spinocerebellar ataxias (SCAs) are a group of neurodegenerative genetic diseases characterized by movement disorders that can affect nutritional status and body composition. This study sought to assess body composition in SCA3 and SCA10 patients. Methods: Anthropometric assessments and bioelectric impedance analysis were performed in 46 SCA3 and SCA10 patients and 76 controls of both genders. Results: Of the patients, 69.6% had SCA3 and 58.7% were women. SCA3 patients had significantly lower percentages of body fat (%BF) than controls (15.0 ± 6.1 vs. 20.6 ± 7.1; p=0.014) and (22.4 ± 6.9 vs. 30.1 ± 6.0; p<0.001), respectively. Among the women, there was a statistically significant difference in %BF between SCA3 and SCA10 patients (22.4 ± 6.9 vs. 32.4 ± 4.9; p<0.001). Male and female SCA3 patients had significantly lower fat-free mass (FFM) than controls [50.6 kg (46.9–54.7) vs. 58.6 kg (52.6–63.9); p=0.001] and [38.2 kg (35.1–42.6) vs. 42.8 kg (39.7–46.1); p=0.004], respectively. Male SCA10 patients also had lower FFM than controls [51.2 kg (47.1–55.4) vs. (52.6–63.9); p=0.008]. Female SCA10 patients had significantly higher FFM than controls and SCA3 patients [45.0 kg (43.3–45.6) vs. 42.8 kg (39.7–46.1); p=0.004] and [45.0 kg (43.3–45.6) vs. 38.2 kg (35.1–42.6); p=0.004], respectively. There was moderate correlation (−0.42) between disease duration and muscle mass (MM), and weak (−0.38) between SARA (Scale for the Assessment and Rating of Ataxia) and MM in SCA3. In SCA10, there was no significant correlation between these variables. Conclusion: Female SCA3 patients had more body composition changes than female SCA10 patients, mainly in relation to FFM. SCA3 and SCA10 patients need nutritional follow-up to minimize body compartment changes.
AB - Background: Spinocerebellar ataxias (SCAs) are a group of neurodegenerative genetic diseases characterized by movement disorders that can affect nutritional status and body composition. This study sought to assess body composition in SCA3 and SCA10 patients. Methods: Anthropometric assessments and bioelectric impedance analysis were performed in 46 SCA3 and SCA10 patients and 76 controls of both genders. Results: Of the patients, 69.6% had SCA3 and 58.7% were women. SCA3 patients had significantly lower percentages of body fat (%BF) than controls (15.0 ± 6.1 vs. 20.6 ± 7.1; p=0.014) and (22.4 ± 6.9 vs. 30.1 ± 6.0; p<0.001), respectively. Among the women, there was a statistically significant difference in %BF between SCA3 and SCA10 patients (22.4 ± 6.9 vs. 32.4 ± 4.9; p<0.001). Male and female SCA3 patients had significantly lower fat-free mass (FFM) than controls [50.6 kg (46.9–54.7) vs. 58.6 kg (52.6–63.9); p=0.001] and [38.2 kg (35.1–42.6) vs. 42.8 kg (39.7–46.1); p=0.004], respectively. Male SCA10 patients also had lower FFM than controls [51.2 kg (47.1–55.4) vs. (52.6–63.9); p=0.008]. Female SCA10 patients had significantly higher FFM than controls and SCA3 patients [45.0 kg (43.3–45.6) vs. 42.8 kg (39.7–46.1); p=0.004] and [45.0 kg (43.3–45.6) vs. 38.2 kg (35.1–42.6); p=0.004], respectively. There was moderate correlation (−0.42) between disease duration and muscle mass (MM), and weak (−0.38) between SARA (Scale for the Assessment and Rating of Ataxia) and MM in SCA3. In SCA10, there was no significant correlation between these variables. Conclusion: Female SCA3 patients had more body composition changes than female SCA10 patients, mainly in relation to FFM. SCA3 and SCA10 patients need nutritional follow-up to minimize body compartment changes.
KW - Anthropometry
KW - Bioelectric impedance
KW - Body composition
KW - Fat free mass
KW - Genetic disease
KW - Muscle mass
KW - Neurodegenerative disease
KW - Nutritional status
KW - Spinocerebellar ataxias
UR - http://www.scopus.com/inward/record.url?scp=85046663336&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046663336&partnerID=8YFLogxK
U2 - 10.1080/1028415X.2018.1469282
DO - 10.1080/1028415X.2018.1469282
M3 - Article
C2 - 29734917
AN - SCOPUS:85046663336
SN - 1028-415X
VL - 23
SP - 49
EP - 54
JO - Nutritional Neuroscience
JF - Nutritional Neuroscience
IS - 1
ER -